Medicines & Supplements A to Z > Itraconazole
Last updated on 09/07/2021.
GENERIC NAME: Itraconazole
CHINESE NAME: 伊曲康唑
BRAND NAME(S) IN HONG KONG: Sporanox, Inox, Itracon
DRUG CLASS: Antifungals
SUB CLASS: Triazoles
USED FOR: Aspergillosis, Blastomycosis, Candidiasis, Histoplasmosis, Nail fungal infections
AVAILABLE DOSAGE FORMS:
– 100mg (capsules)
– 100mg (tablets)
– 10mg/ml (oral solution)
What is Itraconazole for?
Itraconazole belongs to a class of medication called triazole antifungals. It is indicated for treating various fungal infection, including aspergillosis, blastomycosis, candidiasis, histoplasmosis, and onychomycosis
How to use it?
Itraconazole can be taken orally as capsules, solution or tablets. Note that oral solution and oral capsules should not be used interchangeably, especially for candidiasis. Swallow capsule whole. Do not crush, chew, or break.
Listed below are the indications and the dosages.
Solution or capsules: 200 mg once or twice daily for at least 3 months.
Blastomycosis and Histoplasmosis:
Solution or capsules: 200 mg once daily, and can be increased up to 200 mg twice daily in more severe situations. Duration should be at least 3-6 months.
Solution: 200 mg once daily for 14-28 days.
Solution: 200 mg once daily for 7-14 days.
Onychomycosis (toenails with or without fingernail involvement):
Capsules or tablets: 200 mg once daily for 12 weeks.
Onychomycosis (fingernails only):
Capsules or tablets: 200 mg twice daily for 1 week, off drug for 3 weeks, then repeat 200 mg twice daily for 1 week.
What are the side effects of Itraconazole?
Common side effects of Itraconazole include diarrhea, nausea, vomiting, headache, abdominal pain, upper respiratory tract infection, and fever.
Who should not take Itraconazole?
– People who are allergic to Itraconazole or any component of the formulation
– Treatment of onychomycosis in patients with congestive heart failure or history of congestive heart failure
– Treatment of onychomycosis in women who are pregnant or contemplating pregnancy
– Concurrent administration of certain drugs, including Ivabradine, Lovastatin, Methadone, Simvastatin, Dronedarone, etc.
– Do not drive or operate machinery until you know the effect of the medicine.
– Formulations are not interchangeable.
– When treating oropharyngeal and esophageal candidiasis, solution should be swished vigorously in the mouth (10 mL at a time), then swallowed.
– Since this drug is contraindicated and interacts with many other drugs, tell your doctor or pharmacist if you are taking other medicines before starting Itraconazole.
Common dosing schedule:
Itraconazole capsules and tablets should be administered with a full meal, whereas Itraconazole oral solution should be taken on an empty stomach.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Itraconazole may interact with:
– Anticonvulsants, e.g. Carbamazepine, Phenytoin
– Calcium channel blockers, e.g. Verapamil, Diltiazem
– Lipid-regulating drugs, e.g. Atorvastatin, Simvastatin
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
Where to buy Itraconazole in Hong Kong?
In Hong Kong, Itraconazole is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Itraconazole in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.