Medicines & Supplements A to Z > Ivabradine

Ivabradine

Last updated on 06/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Ivabradine

CHINESE NAME: 伊伐雷定

BRAND NAME(S) IN HONG KONG: Coralan 心健朗

DRUG CLASS: Antiarrhythmics

SUB CLASS: Selective sinus node If channel inhibitors

USED FOR: Heart failure with reduced ejection fraction

AVAILABLE DOSAGE FORMS:
– 5mg, 7.5mg (tablets)

What is Ivabradine for?

Ivarbradine belongs to a class of medication called selective sinus node If channel inhibitors. It can regulate the electrical signals in the heart and slow down heart rate so the heart can pump more blood when it contracts. It is mainly used to treat heart failure and reduce the risk of hospitalization for worsening heart failure. On the other hand, it has been suggested to be a second-line treatment for stable angina (off-label use).

How to use it?

Ivabradine can be taken orally as tablets. 

Heart failure:
The usual initial dose is 5 mg twice daily. After 2-4 weeks taking the medication, adjust the dose based on heart rate (refer below) to achieve a resting heart rate between 50-60 beats per minute (bpm). 

Note: A lower initial dose may be required in some special conditions (e.g. history of conduction defects)

Heart rate > 60 bpm: 
Increase dose by 2.5 mg twice daily up to a maximum dose of 7.5 mg twice daily
Heart rate 50-60 bpm:
Maintain dose
Heart rate < 50 bpm or signs and symptoms of bradycardia:
Decrease dose by 2.5 mg twice daily; if current dose is 2.5 mg twice daily, discontinue therapy

Stable angina:
5 mg twice daily, and can be increased after 3-4 weeks if symptoms persist and heart rate is >60 bpm, up to 7.5 mg twice daily.

What are the side effects of Ivabradine?

The common side effects of Ivabradine include bradycardia, hypertension, atrial fibrillation and phosphenes.

Who should not take Ivabradine?

– Patients with severe hypotension, severe bradycardia, severe hepatic impairment
– Patients with acute decompensated heart failure, third-degree AV block, sinoatrial block, or sick sinus syndrome

Pharmacist Tips:

– Continue taking Ivabradine even when you feel well.
– Avoid driving or other activities where sudden changes in light intensity may occur until drug effects are realized, due to potential for phosphenes.

Common dosing schedule:
Ivabradine should be administered with food to increase absorption. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Ivabradine may interact with:
– Itraconazole
– Rifampicin
– St. John’s wort
– Digoxin
– Macrolide antibiotics, e.g. Clarithromycin, Erythromycin
– Calcium channel blockers, e.g. Verapamil, Diltiazam

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Ivabradine in Hong Kong?

In Hong Kong, Ivabradine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Ivabradine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.