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Lovastatin

Last updated on 23/03/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Lovastatin 

CHINESE NAME: 洛伐他汀

BRAND NAME(S) IN HONG KONG: Apo-Lovastatin, Cholvatin, Cysin, Lovatin, Lozutin, Medostatin, Ovastar 

DRUG CLASS: HMG-CoA reductase inhibitor; Cholesterol lowering drug

USED FOR: Elevated blood lipids, prevention of cardiovascular events

OTHER DRUGS IN THE SAME CLASS: Atorvastatin, Fluvastatin, Pravastatin, Rosuvastatin, Simvastatin

AVAILABLE DOSAGE FORMS: 20mg (tablets)

What is Lovastatin for?

Lovastatin is a cholesterol lowering drug that works like Atorvastatin, which is primarily by blocking the enzyme involved in cholesterol synthesis, especially in the liver, and hence reduces cholesterol levels. It is the first-line medication used for hypercholesterolaemia or hyperlipidemia (elevated blood cholesterol).

The detailed indications of Lovastatin include

– Primary hypercholesterolemia or combined (mixed) hyperlipidemia in patients who did not respond adequately to diet and other appropriate measures

– Heterozygous familial hypercholesterolemia in patients who have not responded adequately to diet and other appropriate measures

– Prevention of cardiovascular events in patients with cardiovascular disease or at high risk of having a cardiovascular event (e.g. people who smoke, people with diabetes).

How to use it?

Lovastatin is taken by mouth as conventional tablets. You usually start with 10-20 mg daily in the evening with food. Your doctor may increase the dose up to 80 mg at least every 4 weeks according to your blood cholesterol level. 

If you are taking Lovastatin for prevention of cardiovascular events, the dose to be taken depends on your risk level (such as family history of hypercholesterolemia, high blood pressure) , ranging from 20-40 mg once a day. 

What are the side effects of Lovastatin?

The most common side effects of Lovastatin are muscle pain, muscle weakness, and shoulder pain. Rare side effects include an increased risk of diabetes, cognitive impairment (inability to focus or remember) and rhabdomyolysis (severe muscle breakdown).

Who should not take Lovastatin?

– Patients with active liver disease
– People allergic to Lovastatin or other ingredients of formulation
Pregnant or breastfeeding women, or those who plan to become pregnant

Pharmacist Tips:

– Seek medical attention immediately if there is any unexplained muscle pain.
– Take adequate contraception during and 1 month after therapy if you are a female patient with childbearing potential.
– Avoid consumption of large amounts of grapefruit and grapefruit juice while you are on this medication.
– Reductions in blood cholesterol will be the best when Lovastatin is used with diet and exercise. 

Common dosing schedule:
You can take Lovastatin once a day with the evening meal. Take the drug at the same time every day. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Lovastatin may interact with:
– Amiodarone
– Antifungal agents, e.g. Itraconazole, Ketoconazole, Posaconazole
Cyclosporine
– Digoxin
– Protease inhibitors, e.g. Boceprevir, Telaprevir
– Red yeast rice
– Some antibiotics, e.g. Clarithromycin, Erythromycin
– St John’s Wort 

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Lovastatin in Hong Kong?

In Hong Kong, Lovastatin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Lovastatin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.