Medicines & Supplements A to Z > Megestrol


Last updated on 15/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  



BRAND NAME(S) IN HONG KONG: Megestrol 麥格斯, Megaplex

DRUG CLASS: Endocrine Drugs

SUB CLASS: Progestins

USED FOR: Treatment of breast cancer, Cancer hormone therapy, Endometrial hyperplasia

AVAILABLE DOSAGE FORMS: 40mg, 160mg (tablets)

What is Megestrol for?

Megestrol is a progestin belonging to a class of medications called endocrine drugs, resembling the structure of progesterone, which is a female sex hormones influencing metabolic processes. It is used for the treatment of breast cancer, cancer hormone therapy and endometrial hyperplasia.

How to use it?

Megestrol is available as tablets in Hong Kong. It differs little regarding what time in a day you take the pills, but it has to be consistent between days. 

Advanced breast cancer
40 mg 4 times daily for at least 2 months.

Advanced endometrial cancer
40-320 mg daily in divided doses for at least 2 months.

What are the side effects of Megestrol?

Common side effects of Megestrol include, but not limited to, hypertension, headache, skin rash, high blood glucose, diarrhea, impotence and weakness.

Who should not take Megestrol?

– People allergic to Megestrol or any component of the formulation.

Pharmacist Tips:

– Avoid using in elderly patients as insufficient data to prove its safety.

Common dosing schedule:
Megestrol is used in divided doses, commonly 4 times daily. Try to divide to make the doses equivalent. For example, when 120 mg is to be taken, 40 mg 3 times daily is to be taken.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Megestrol may interact with:
– Antidiabetic agents, e.g. Metformin, Glipizide, Insulin
– Systemic corticosteroids, e.g. Cortisone, Hydrocortisone, Prednisone
– Anticoagulants, e.g. Heparin, Warfarin, Dabigatran
– Dofetilide

Megestrol may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Megestrol in Hong Kong?

In Hong Kong, Megestrol is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Megestrol in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.