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Dabigatran

Last updated on 19/03/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Dabigatran

CHINESE NAME: 達比加群

BRAND NAME(S) IN HONG KONG: Pradaxa 普栓達

DRUG CLASS: Anticoagulant, Non-vitamin K antagonist oral anticoagulant (NOAC)/direct oral anticoagulant (DOAC)

USED FOR: Nonvalvular atrial fibrillation, Deep vein thrombosis, Pulmonary embolism

OTHER DRUGS IN THE SAME CLASS: Apixaban, Edoxaban, Rivaroxaban

What is Dabigatran for?

Dabigatran belongs to a class of medications called Direct or Novel Oral Anticoagulant. It is used to treat blood clots, including that in deep vein and in major blood vessel in the lung, and to prevent potential stroke in atrial fibrillation patients (but not for those with abnormal heart valve). 

How to use it?

Dabigatran can be taken orally. 

For preventing stroke in atrial fibrillation and treating DVT or PE, the usual dose is 150 mg twice daily.

For preventing DVT or PE after hip replacement, the initial dose is 110 mg 1-4 hours after surgery. After the patient has stopped bleeding on the first day, the dose is 220 mg once daily for 28-35 days.

A lower dose is used in patients with poorer kidney function.

What are the side effects of Dabigatran? 

The most common side effect is higher chance of bleeding, for example easier bruising, black tarry stools (gastrointestinal bleeding) , pink urine (bleeding in the urinary tract), which may lead to anemia. 

Who should not take Dabigatran?

– Anyone who is sensitive to Dabigatran or any ingredients in the medicine
– Anyone actively bleeding
– Anyone with severe kidney impairment

Pharmacist Tips:

As Dabigatran increases the chance of bleeding, be careful and avoid injury. Use a soft toothbrush and an electric razor. Make sure you take every dose, as you may risk a potentially fatal blood clot. If you have signs of abnormal bleeding, please find your doctor right away.

Common dosing schedule:
Dabigatran can be taken with or without food. Swallow the whole capsule. Do not chew, break, crush or dissolve. Take it at the same time on a daily basis. Unlike conventional anticoagulants (e.g. warfarin), Dabigatran has less dietary restrictions.

What if I miss a dose?
Dabigatran is usually taken twice daily. If you remember it within 6 hours, take the missed dose immediately; if is is over 6 hours, skip the missed dose and go back to your normal dosing schedule. Do not take two doses at the same time. Please record the date of the missed dose and tell the doctor in the next follow-up.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Dabigatran may interact with:
– Antiplatelet agents (e.g. aspirin, clopidogrel)
– Nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, celecoxib)
– Cyclosporine

Please notify your doctor or pharmacist if you are taking the above medication, as dosage adjustments might be needed.

Where to buy Dabigatran in Hong Kong?

In Hong Kong, Dabigatran is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk/

Need more information?

For detailed information about the use of Dabigatran in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.