Medicines & Supplements A to Z > Prochlorperazine

Prochlorperazine

Last updated on 12/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Prochlorperazine

CHINESE NAME: 丙氯拉嗪

BRAND NAME(S) IN HONG KONG: Stemetil

DRUG CLASS: Antipsychotics, Antianxiety agents, Antivertigo agents, Antiemetics

SUB CLASS: Typical antipsychotics, Phenothiazines

USED FOR: Nausea and vomiting, vertigo, anxiety, schizophrenia, mania

AVAILABLE DOSAGE FORMS:
– 5 mg (tablets)
– 12.5 mg (injections)

What is Prochlorperazine for?

Prochlorperazine belongs to a class of medications called typical antipsychotics. It works by balancing the chemicals and decreasing abnormal excitement in the brain, and hence restores normal mood, mind, and behaviour. Prochlorperazine is therefore used to relieve nausea and vomiting, anxiety, vertigo in Labyrinthine disorders, and is used to treat psychotic disorders such as schizophrenia.

How to use it?

Prochlorperazine can be taken by mouth. It may be taken with or without food. Taking Prochlorperazine with food may help to reduce gastrointestinal discomfort.

The oral dosages for Prochlorperazine are listed below.

Vertigo in patients with Meniere’s syndrome or Labyrinthine disorders
Adult
5 mg three times daily, which may be increased gradually to 30 mg daily in divided doses. After several weeks, reduce the dose to 5-10 mg daily.
Elderly
Dose reduction may be necessary.

Nausea and vomiting
Adult
For prevention of nausea and vomiting, use 5-10 mg 2-3 times daily.
For treatment of nausea and vomiting, use 20 mg initially, followed by 10 mg after 2 hours if necessary.
Elderly
Dose reduction may be necessary.
Child over 1 year
Body weight >10 kg: 0.25 mg/kg body weight 2-3 times daily.

Short term management of severe anxiety
Adult
As adjunct therapy. Initially 15-20 mg daily in divided doses.May increase to a maximum of 40 mg daily if necessary.
Elderly
Dose reduction may be necessary.

Mania, Schizophrenia
Adult
Initially 12.5 mg twice daily for 7 days, then gradually increase in 4-7 days interval until satisfactory response is achieved. Usual dose is 75-100 mg daily.
Elderly
Dose reduction may be necessary.

What are the side effects of Prochlorperazine?

Common side effects of Prochlorperazine include agitation, amenorrhoea, constipation, dizziness, drowsiness, dry mouth, erectile dysfunction, insomnia, parkinsonism, seizure, tremor and vomiting.

Who should not take Prochlorperazine?

– People allergic to Prochlorperazine or any component of the formulation
– People who are allergic to phenothiazine medications
– Children under 2 years of age or weighing under 9 kg (20 lbs)
– Patients under comatose states.

Pharmacist Tips:

– This medication may cause drowsiness. Avoid driving or operating machinery until you know how you respond to Prochlorperazine.
– Prochlorperazine may impair your ability to regulate heat. Avoid strenuous exercise, exposure to excessive heat, or dehydration.
– Rise slowly from a sitting or lying position as this medication can cause postural hypotension.
– Report to your doctor immediately if you experience extrapyramidal symptoms, such as involuntary or uncontrollable movements, restlessness, muscle spasms and tremors.
– This medication may cause false readings on some types of pregnancy tests.
– Avoid alcohol and antacids while taking this medication.

Common dosing schedule:
Prochlorperazine is taken twice daily. It may be taken with or without food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Prochlorperazine may interact with:
– Tricyclic antidepressants, e.g. Amitriptyline, Doxepin
– Antipsychotics, e.g. Aripiprazole, Risperidone, Olanzapine
– Antacids
Lithium

Please notify your doctor or pharmacist if you are taking the above medications, dosage adjustments might be needed.

Where to buy Prochlorperazine in Hong Kong?

In Hong Kong, Prochlorperazine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Prochlorperazine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.