Medicines & Supplements A to Z > Amitriptyline

Amitriptyline

Last updated on 18/03/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Amitriptyline

CHINESE NAME: 阿米替林

BRAND NAME(S) IN HONG KONG: Endep, Trepiline, Tripsyl, Tripta, Qualitriptine

DRUG CLASS: Tricyclic antidepressant 

USED FOR: Depression, neuropathic pain, migraine

OTHER DRUGS IN THE SAME CLASS: Clomipramine, Imipramine, Nortriptyline, Trimipramine

What is Amitriptyline for?

Amitriptyline belongs to a class of medications called Tricyclic antidepressants. It is used to treat depression and alleviate neuropathic pain. It can also treat migraines.

How to use it?

Amitriptyline can be taken orally. 

For depression, the usual adult dosage is 100-300 mg daily. 

For neuropathic pain and migraine, the initial dosage is 10-25 mg once daily, and it may be gradually increased based on the response, up to 150 mg daily.

What are the side effects of Amitriptyline? 

Common effects include dizziness, tiredness, headache, weight gain, confusion, anxiety, altered heartbeat, lower blood pressure when standing or sitting (orthostatic hypotension), loss of libido, and sleep disturbances.

Who should not take Amitriptyline?

– Anyone who is sensitive to Amitriptyline
– Anyone with severe liver impairment or acute heart failure

Pharmacist Tips:

– To lower the chance of feeling dizzy, stand up slowly when you have been sitting or lying down.
– It might take a few weeks for Amitriptyline to reach its full effect.
– Do not stop taking Amitriptyline suddenly as you may suffer from withdrawal symptoms, such as nausea and dizziness.

Common dosing schedule:
Amitriptyline is usually taken at bedtime since it can cause sedation. When possible take higher doses in the late afternoon or evening. Avoid using alcohol while taking Amitriptyline.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Amitriptyline may interact with:
Chlorpheniramine
Carbamazepine
– Muscle relaxants, e.g. Orphenadrine, Baclofen)

Please notify your doctor or pharmacist if you are taking the above medication, as dosage adjustments might be needed.

Where to buy Amitriptyline in Hong Kong?

In Hong Kong, Amitriptyline is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk/

Need more information?

For detailed information about the use of Amitriptyline in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.