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Levodopa-Carbidopa

Last updated on 13/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Levodopa + Carbidopa

CHINESE NAME: 卡左雙多巴, 左旋多巴/卡比多巴

BRAND NAME(S) IN HONG KONG: Apo-Levocarb

DRUG CLASS: Antiparkinsonian agents

SUB CLASS: Dopamine precursor, Decarboxylase inhibitors

USED FOR: Parkinson’s disease

AVAILABLE DOSAGE FORMS:
– 100mg/25mg, 250mg/25mg (tablets)
– 200mg/50mg (prolonged-release tablets)

What is Levodopa-Carbidopa for?

Levodopa-Carbidopa is a combination of two antiparkinsonian agents. The function of Levodopa, which is a dopamine precursor, is enhanced in the brain by Carbidopa in the way of preventing the breakdown of Levodopa. It is indicated for the treatment of Parkinson’s disease.

How to use it?

Levodopa-Carbidopa can be taken orally as conventional tablets or prolonged-release tablets. If needed, the use of conventional tablets can be converted into controlled-release tablets, but it has to be done under the supervision of doctors or pharmacists.

Conventional tablets:
100mg/25mg three times daily, and can be increased by 100mg/25mg (1 tablet) every 1-2 days, up to 8 tablets per day. When used in a high dose, 250mg/25mg may be used for substitution of 100mg/25mg tablets.

Prolonged-release tablets (for patients not receiving Levodopa) :
Initiate 200mg/50mg twice daily, and can be increased gradually up to maximum 2400mg/day (Levodopa dose) if needed.

What are the side effects of Levodopa-Carbidopa?

Common side effects of Levodopa-Carbidopa include nausea, vomiting, anorexia, hallucination, headache, and dyskinesia.

Who should not take Levodopa-Carbidopa?

– People who are allergic to Levodopa, Carbidopa, or any component of the formulation
– Patients with narrow angle glaucoma

Pharmacist Tips:

– Avoid driving or operating machinery until you know how you respond to Levodopa-Carbidopa as it may cause drowsiness.
– Avoid alcohol use while taking this medication.
– Do not stop taking Levodopa-Carbidopa suddenly as it may cause a serious side effect.
– A dark color (red, brown, or black) may show up in your saliva, urine, or sweat. This is not harmful but may discolor your clothes.
– This drug may “wear off” as the time for your next dose gets closer. Tell your doctor if this happens and it bothers you.

Common dosing schedule:
Levodopa-Carbidopa can be taken with or without food, but avoid high-fat or high-protein meals apart from administration. 

This schedule is for reference only, adjustments may be made according to individual needs. 

Some common medications Levodopa-Carbidopa may interact with:
– Monoamine oxidase inhibitors, e.g. Selegiline, Rasagiline
– Iron salts or multivitamins containing iron salts
– Dopamine antagonists, e.g. Metoclopramide, Risperidone
– Antipsychotics, e.g. Haloperidol, Risperidone, Chlorpromazine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Levodopa-Carbidopa in Hong Kong?

In Hong Kong, Levodopa-Carbidopa is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Levodopa-Carbidopa in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.