Medicines & Supplements A to Z > Chlorpromazine

Chlorpromazine

Last updated on 09/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Chlorpromazine

ALTERNATIVE NAME: CPZ

CHINESE NAME: 氯丙嗪

BRAND NAME(S) IN HONG KONG: Chlozine 

DRUG CLASS: Antiemetics, Antipsychotics

SUB CLASS: Phenothiazines, Typical antipsychotics

USED FOR: Schizophrenia, Bipolar disorder, Nausea and vomiting, Intractable hiccups, Behavioral problems in children

AVAILABLE DOSAGE FORMS:
– 25mg, 50mg, 100mg (tablets)

What is Chlorpromazine for?

Chlorpromazine belongs to classes of medications called phenothiazines and typical antipsychotics. It can suppress a chemical in the brain to control nausea/vomiting and psychiatric disorders. It is used for many indications, including schizophrenia, bipolar disorder, nausea/vomiting, intractable hiccups, and behavioral problems in children.

How to use it?

Chlorpromazine is taken orally as tablets. Listed below are the indications and the dosages. 

Schizophrenia:
25-200 mg/day in 2-4 divided doses, and may increase dose based on response and tolerability in 20-50 mg increments every ≥3 days up to 800 mg/day in 2-4 divided doses.

Nausea and vomiting:
25 mg every 4-8 hours as needed, up to 150 mg/day.

Bipolar disorder (manic episode):
25 mg three times daily, and may increase dose based on response and tolerability in 20-50 mg increments every ≥3 days up to 400 mg/day.

Intractable hiccups:
25-50 mg three to four times daily.

Severe behavior problems (acute agitation) in patients 6months – 12years:
0.55 mg/kg every 4-6 hours as needed. In more severe cases, a dose of 50-100 mg/day may be needed. In older children or adolescents, a dose of 200 mg/day or higher may be required.

What are the side effects of Chlorpromazine?

Common side effects of Chlorpromazine include dry mouth, constipation, blurred vision, weight gain, orthostatic hypotension, tremor, akathisia, or somnolence.

Who should not take Chlorpromazine?

– People who are allergic to phenothiazines
– Concomitant use with large amounts of alcohol, barbiturates, or opioids
– Patients in coma state

Pharmacist Tips:

– Do not drive or operate machinery until you know the effect of the medicine.
– You may get sunburned more easily. Use sunscreen and avoid tanning beds.
– Do not stop taking Chlorpromazine suddenly as it can cause withdrawal symptoms.
– Avoid drinking alcohol while taking this drug.

Common dosing schedule:
Chlorpromazine can be taken with or without food. However, you may take it with food if you experience an upset stomach. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Chlorpromazine may interact with:
Lithium
Fluvoxamine
Ciprofloxacin
– Thiazide diuretics, e.g. Hydrochlorothiazide
– Oral contraceptives, e.g. Levonorgestrel
– Antihypertensives, e.g. Propranolol, Verapamil
– Antiarrhythmics, e.g. Amiodarone, Sotalol

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Chlorpromazine in Hong Kong?

In Hong Kong, Chlorpromazine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Chlorpromazine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.