Medicines & Supplements A to Z > Selegiline


Last updated on 07/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Selegiline




DRUG CLASS: Antiparkinsonian agents

SUB CLASS: Monoamine oxidase type B (MAO-B) inhibitors

USED FOR: Parkinson’s disease

– 5mg (tablets)

What is Selegiline for?

Selegiline belongs to a class of medication called Monoamine oxidase type B (MAO-B) inhibitors. It prevents the breakdown of dopamine in the brain to increase dopamine concentration so as to prolong its action. It usually acts as an initial monotherapy in mild Parkinson’s disease, or an adjunct with levodopa/carbidopa in later stages.

How to use it?

Selegiline can be taken orally as tablets. The usual dose is 5 mg twice daily, or 5-10 mg daily in the morning.

What are the side effects of Selegiline?

Common side effects of Selegiline include nausea, vomiting, constipation, orthostatic hypotension, dizziness, hallucinations or insomnia. 

Who should not take Selegiline?

– People who are allergic to Selegiline or any component of the formulation
– Concomitant use of Meperidine (Pethidine), Tramadol,  Dextromethorphan or tricyclic antidepressants.

Pharmacist Tips:

– Avoid foods and drinks that are high in tyramine, because your blood pressure could get dangerously high. Tyramine-rich foods include most cheese, most alcohol, cured meat (such as salami), sauerkraut, and soy sauce.
– Avoid driving or operating machinery until you know how you respond to Selegiline.
– Do not stop taking Selegiline suddenly as it may cause withdrawal symptoms.

Common dosing schedule:
Selegiline should be taken with meals in the morning to minimize any trouble sleeping and upset stomach. Take with breakfast, and lunch if it is twice-daily dosing.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Selegiline may interact with:
– Antidepressants, e.g. Fluoxetine, Venlafaxine
– Monoamine oxidase inhibitors, e.g. Rasagiline
– Antiepileptics, e.g. Carbamazepine
– Cough and cold medicine, e.g. Dextromethorphan

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Selegiline in Hong Kong?

In Hong Kong, Selegiline is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Selegiline in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.