Medicines & Supplements A to Z > Entacapone

Entacapone

Last updated on 13/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Entacapone

CHINESE NAME: 恩他卡朋

BRAND NAME(S) IN HONG KONG: Comtan 諾康停

DRUG CLASS: Antiparkinsonian agents

SUB CLASS: COMT inhibitors

USED FOR: Parkinson’s disease

AVAILABLE DOSAGE FORMS:
– 200mg (tablets)

What is Entacapone for?

Entacapone belongs to a class of medications called COMT inhibitors. When used with Levodopa, Entacapone can enhance its action by preventing its metabolism before entering into the brain. It is indicated for the adjunctive treatment of Parkinson’s disease with Levodopa/Carbidopa.

How to use it?

Entacapone is taken orally as tablets. The usual dose is 200 mg with each dose of Levodopa/Carbidopa, up to a maximum of 8 times daily.

In the market, there are some three-in-one-tablet products, such as Stalevo® (Entacapone/Levodopa/Carbidopa), which can provide a more convenient drug selection and administration.

What are the side effects of Entacapone?

Common side effects of Entacapone include brown-orange urine, nausea, abdominal pain, diarrhea, vomiting, dry mouth, and dyskinesia.

Who should not take Entacapone?

People who are allergic to Entacapone or any component of the formulation.

Pharmacist Tips:

– Avoid driving or operating machinery until you know how you respond to Entacapone as it may cause drowsiness.
– Avoid drinking alcohol during the treatment.
– Do not stop taking Entacapone suddenly as it may worsen your symptoms.
– This drug may change the color of urine to brown or orange. This is normal and not harmful.

Common dosing schedule:
Entacapone can be taken with or without food, but it must be administered in association with Levodopa/Carbidopa. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Entacapone may interact with:
– Warfarin
– Opioids, e.g. Tramadol, Codeine, Fentanyl
– Monoamine oxidase inhibitors, e.g. Selegiline, Moclobemide

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Entacapone in Hong Kong?

In Hong Kong, Entacapone is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Entacapone in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.