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Trifluoperazine

Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Trifluoperazine

CHINESE NAME: 三氟拉嗪

BRAND NAME(S) IN HONG KONG: Apo-Trifluoperazine

DRUG CLASS: Antipsychotics, Antianxiety agents, Antiemetics

SUB CLASS: Typical antipsychotics, Phenothiazines

USED FOR: Nausea and vomiting, anxiety, schizophrenia

AVAILABLE DOSAGE FORMS: 1 mg, 5 mg (tablets)

What is Trifluoperazine for?

Trifluoperazine belongs to a class of medications called typical antipsychotics. It works by balancing the chemicals and decreasing abnormal excitement in the brain, and hence restores normal mood, mind, and behaviour. Trifluoperazine is used to relieve nausea and vomiting, anxiety, and is also used to treat psychotic disorders such as schizophrenia.

How to use it?

Trifluoperazine can be taken by mouth. It should be taken with food, which may help to reduce gastrointestinal discomfort. Do not take Trifluoperazine within 2 hours of taking antacids.

Nausea and vomiting
Adult
Initially 1-2 mg twice daily. Adjust dose according to response and severity. May increase to a maximum of 6 mg daily in divided doses if necessary.
Elderly
Initiate at a reduced dose, then gradually increase based on response and tolerability.

Short term management of anxiety
Adult
As adjunct therapy. Initially 1-2 mg twice daily. Adjust dose according to response and severity. May increase to a maximum of 6 mg daily in divided doses if necessary. Maximum treatment duration is 12 weeks.
Elderly
Initiate at a reduced dose, then gradually increase based on response and tolerability.

Schizophrenia, psychoses
Adult
Initially 2-5 mg twice daily, then gradually increase to the usual dose range of 15-20 mg daily. Adjust dose according to response and tolerability. Doses of 40 mg daily may be required in severe or resistant cases.
Elderly
Initiate at a reduced dose, then gradually increase based on response and tolerability.

What are the side effects of Trifluoperazine?

Common side effects of Trifluoperazine include reduced alertness, anxiety, reduced appetite, confusion, fatigue, agitation, amenorrhoea, constipation, dizziness, drowsiness, dry mouth, erectile dysfunction, insomnia, parkinsonism, seizure, tremor and vomiting.

Who should not take Trifluoperazine?

– People allergic to Trifluoperazine or any component of the formulation
– People who are allergic to phenothiazine medications
– Patients with reduced liver function or liver failure
– Patients with central nervous system depression
– Patients with blood dyscrasias or bone marrow depression

Pharmacist Tips:

– This medication may cause drowsiness. Avoid driving or operating machinery until you know how you respond to Trifluoperazine.
– Trifluoperazine may impair your ability to regulate heat. Avoid strenuous exercise, exposure to excessive heat, or dehydration.
– Rise slowly from a sitting or lying position as this medication can cause postural hypotension.
– Report to your doctor immediately if you experience extrapyramidal symptoms, such as involuntary or uncontrollable movements, restlessness, muscle spasms and tremors.

Common dosing schedule:
Trifluoperazine is taken twice daily. Take Trifluoperazine with food to minimise gastrointestinal irritation.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Trifluoperazine may interact with:
– Medicines for lowering blood pressure, e.g. Atenolol, Verapamil
– Tricyclic antidepressants, e.g. Amitriptyline, Doxepin
Warfarin and other anticoagulants
– Antacids

Trifluoperazine may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medications, dosage adjustments might be needed.

Where to buy Trifluoperazine in Hong Kong?

In Hong Kong, Trifluoperazine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Trifluoperazine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.