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Brexpiprazole

Last updated on 12/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Brexpiprazole

CHINESE NAME: 匹依搏挫

BRAND NAME(S) IN HONG KONG: Rexulti 銳思定

DRUG CLASS: Antipsychotics

SUB CLASS: Atypical antipsychotics

USED FOR: Schizophrenia, major depression

AVAILABLE DOSAGE FORMS:
– 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg (tablets)

What is Brexpiprazole for?

Brexpiprazole belongs to a class of medications called atypical antipsychotics. It works by balancing the chemicals in your brain and hence restores normal mood, mind, and behaviour. Brexpiprazole is therefore used to treat schizophrenia and major depressive disorder.

How to use it?

Brexpiprazole can be taken by mouth. It may be taken with or without food.

Schizophrenia
Adult
Initially 1 mg once daily on days 1-4, may increase to 2 mg once daily on days 5-7, then 4 mg on day 8. Adjust accordingly to patient response and tolerability. Recommended target dose is 2-4 mg once daily, maximum dose is 4 mg daily.

Major depressive disorder
Adult
As adjunct therapy. Initially 0.5 mg or 1 mg once daily. Increase dose at weekly intervals up to the target dose of 2 mg once daily according to patient response and tolerability. Maximum dose is 3 mg daily.

What are the side effects of Brexpiprazole?

Common side effects of Brexpiprazole include agitation, amenorrhoea, constipation, dizziness, drowsiness, dry mouth, erectile dysfunction, insomnia, parkinsonism, seizure, tremor and vomiting.

Who should not take Brexpiprazole?

People allergic to Brexpiprazole or any component of the formulation

Pharmacist Tips:

– This medication may cause sedation. Avoid driving or operating machinery until you know how you respond to Brexpiprazole.
– Do not consume alcohol while on this medication.
– Brexpiprazole can induce suicidal thoughts or behaviours in patients. Report to your doctor or pharmacist if you experience these symptoms.

Common dosing schedule:
Brexpiprazole is taken once daily. It may be taken with or without food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Brexpiprazole may interact with:
– Ketoconazole
– Clarithromycin
– Rifampin
– Carbamazepine
– Phenytoin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Brexpiprazole in Hong Kong?

In Hong Kong, Brexpiprazole is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Brexpiprazole in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.