Medicines & Supplements A to Z > Amoxicillin-Clavulanic Acid
Last updated on 18/03/2021.
GENERIC NAME: Amoxicillin-Clavulanic Acid
CHINESE NAME: 阿莫西林克拉維酸
BRAND NAME(S) IN HONG KONG: Augmentin, AMK
DRUG CLASS: Antibiotics
USED FOR: Bacterial infections
OTHER DRUGS IN THE SAME CLASS: Ampicillin, Dicloxacillin, Nafcillin, Oxacillin, Penicillin V
AVAILABLE DOSAGE FORMS:
– 1.2g (injections)
– 325mg, 625mg, 1g (tablets)
– 156mg/5ml, 457mg/5ml (syrups)
What is Amoxicillin-Clavulanic Acid for?
Amoxicillin-Clavulanic Acid (Augmentin) contains two ingredients, Amoxicillin and Clavulanic Acid. It is an antibiotic used for treating bacterial infections, including but not limited to the following:
– Otitis media (infection of ears)
– Infections due to beta-lactamase-producing strains (where amoxicillin alone is not appropriate), including respiratory tract infections, bone and joint infections, genito-urinary and abdominal infections, cellulitis and animal bites
– Severe dental infections with spreading cellulitis or dental infections not responding to first-line antibiotics
– Prevention of surgical infections
– Acute exacerbation of bronchiectasis
– Acute exacerbation of chronic obstructive pulmonary disease (COPD)
– Acute sinusitis
How to use it?
The dosage of Amoxicillin-Clavulanic Acid is usually based on the Amoxicillin component. The strength of each product, however, may combine the total amount of drug. For example, a 375-mg tablet of Augmentin contains 250 mg of Amoxicillin and 125 mg of Clavulanic acid. The dosage and frequency are specific to the product so always confirm with your doctor or pharmacist.
When taken by mouth, the usual adult dosage is 250 to 500 mg every 8 to 12 hours. The alternate dosage is 875 mg every 12 hours.
For children, your doctor will select the most appropriate Augmentin dose and it will depend on the type of infection, the age of your child, and their body weight. There are several liquid products that are available that have different ratios of Amoxicillin and Clavulanic acid. For example, Augmentin 125/31 mg liquid contains 125 mg of Amoxicillin and 31 mg Clavulanic acid (4:1 ratio), whereas Augmentin 400/57 mg liquid contains 200 mg of Amoxicillin and 28.5 mg of Clavulanic acid (7:1 ratio). The 7:1 ratio allows for higher dosing of Amoxicillin and keeps a similar dose of Clavulanic acid.
General dosage suggestions for children with ear infections are as follows:
Orally using tablets
Child 12-17 years
250/125 mg 3 times daily for 5-7 days, alternatively 500/125 mg 3 times daily for 5-7 days.
Orally using 125/31 suspension
Child 1-11 months
0.25 ml/kg 3 times daily for 5-7 days.
Child 1-5 years
5 ml 3 times daily for 5-7 days, alternatively 0.25 ml/kg 3 times daily for 5-7 days
Orally using 250/62 suspension
Child 6-11 years
5 ml 3 times daily for 5-7 days, alternatively 0.15 ml/kg 3 times daily for 5-7 days.
What are the side effects of Amoxicillin-Clavulanic Acid?
Common side effects of Amoxicillin-Clavulanic Acid (e.g. Augmentin) include diarrhoea, nausea and vomiting, allergy, skin reactions, and overgrowth of yeast which can cause oral thrush or a vaginal yeast infection.
Who should not take Amoxicillin-Clavulanic Acid?
Anyone who is allergic to Amoxicillin.
This drug may reduce the effectiveness of oral contraceptives. Use an additional form of contraceptive method while taking Amoxicillin-Clavulanic Acid.
Common dosing schedule:
Usually taken before meals.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Amoxicillin-Clavulanic Acid may interact with:
– Oral contraceptives
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
Where to buy Amoxicillin-Clavulanic Acid in Hong Kong?
In Hong Kong, Amoxicillin-Clavulanic Acid is a prescription-only medicine. It requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk/
Need more information?
For detailed information about the use of Amoxicillin-Clavulanic Acid in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.