Zofran is a brand medication that contains Ondansetron, which belongs to a class of medications called 5-HT3 receptor antagonists. It works by suppressing a chemical in the brain which causes nausea and vomiting. It is used for the prevention of chemotherapy-induced, radiotherapy-induced, and postoperative nausea and vomiting.
Zofran is available as tablets, orodispersible tablets or injections. On the day of chemotherapy, administer prior to chemotherapy and in combination with a NK-1 receptor antagonist, Dexamethasone (with/without Olanzapine).
For prevention of nausea/vomiting associated with high-emetogenic chemotherapy:
Tablets: 24mg at once
Injections: 8-16 mg at once
For prevention of nausea/vomiting associated with moderate-emetogenic chemotherapy:
Tablets: 8 mg twice daily, with the 1st dose given prior to chemo and the 2nd dose given 8 hours later
Injections: 8-16 mg at once
For prevention of nausea/vomiting associated with low-emetogenic chemotherapy:
Tablets: 8 mg at once before chemotherapy
Injections: 8 mg at once before chemotherapy
For Prevention of nausea/vomiting associated with radiotherapy,
Take 8 mg at once or twice daily, administered 1-2 hours before radiotherapy in combination with Dexamethasone.
Common side effects of Zofran include constipation, fatigue and headache.
Common dosing schedule:
Take with or without food. Please refer to the above section for specific administering instructions.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Zofran may interact with:
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
In Hong Kong, Zofran is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Zofran in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.
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