Medicines & Supplements A to Z > Vincristine

Vincristine

Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Vincristine

CHINESE NAME: 長春新鹼

BRAND NAME(S) IN HONG KONG: Vinracine

DRUG CLASS: Antineoplastics

SUB CLASS: Mitotic inhibitors

USED FOR: Cytotoxic chemotherapy, Treatment of lung cancer, Acute myeloid leukaemia, Treatment of brain cancer

AVAILABLE DOSAGE FORMS:
– 1 mg/ml (injections)

What is Vincristine for?

Vincristine is an antineoplastic that inhibits tubulin from linking together to form microtubules, hence cell divisions cannot be undergone. Therefore, it can be used in the treatment of lung, brain, blood and other cancers.

How to use it?

Vincristine is to be injected only into the veins. Your body surface area will be estimated by the physician to calculate the appropriate dose for the intravenous injection.

Acute lymphoblastic leukaemia, Acute myeloid leukaemia, Brain tumour, Hodgkin’s disease, Neuroblastoma, Non-Hodgkin’s lymphoma, Small cell lung cancer, Wilm’s tumour
Adult and elderly
1.4-1.5 mg/m2 once weekly up to 2 mg weekly with the possible addition of other drugs. The following doses will be adjusted based on body response and tolerance.

Child
1.5-2 mg/m2 once weekly with the possible addition of other drugs. For those lighter than 10 kg, it may be initiated at 0.05 mg/kg once weekly. The following doses will be adjusted based on body response and tolerance.

What are the side effects of Vincristine?

Common side effects of Vincristine include, but not limited to, hypertension, hair loss, headache, diarrhea, dehydration, increased risk of infection and cranial nerve disorder.

Who should not take Vincristine?

Patients with the demyelinating form of Charcot-Marie-Tooth syndrome.

Pharmacist Tips:

– Vincristine must be used to inject into the veins only.
– Vincristine can cause bone marrow suppression, slowing down the formation of white blood cells. Signs like pale skin, lips and nail beds, fatigue and shortness of breath will be observed. This will increase the risk of infection. Report all signs of infection like fever, shortness of breath and sore throat to your physician as soon as possible.

Common dosing schedule:
Vincristine injections are prescribed in institutions by the physicians.

This schedule is for reference only, adjustments may be made according to individual needs. 

Some common medications Vincristine may interact with:
– CYP3A4 inducers, e.g. Diltiazem, Itraconazole, Ritonavir
– CYP3A4 inhibitors, e.g. Clarithromycin, Ketoconazole, Amiodarone
Phenytoin
– Clofazimine
Vasopressin

Vincristine may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Vincristine in Hong Kong?

In Hong Kong, Vincristine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Vincristine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.