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Abatacept

Last updated on 03/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Abatacept

CHINESE NAME: 阿巴西普

BRAND NAME(S) IN HONG KONG: Orencia 恩瑞舒

DRUG CLASS: Immunomodulatory drugs

SUB CLASS: Biologics Disease-Modifying Anti-Rheumatic Drugs, Selective T Cell costimulation modulator

USED FOR: Psoriatic arthritis, Moderate to severe rheumatoid arthritis, Juvenile idiopathic arthritis

AVAILABLE DOSAGE FORMS:
– 150mg, 250mg (injections)
– 250mg (IV infusion)

What is Abatacept for?

Abatacept, which is a biologics disease-modifying anti-rheumatic drug (DMARD), is a selective T Cell costimulation modulator. It can modulate the activity of immune system cells to suppress inflammatory signals causing arthritis, including psoriatic arthritis, rheumatoid arthritis, and juvenile idiopathic arthritis.

How to use it?

Abatacept can be injected subcutaneously, or administered through intravenous infusion. 

For psoriatic arthritis, and moderate to severe rheumatoid arthritis:
IV infusion: Dosing is according to body weight. Following the initial IV infusion, repeat IV infusion at 2 weeks and 4 weeks after the initial infusion, and every 4 weeks thereafter.
<60 kg: 500 mg
60-100 kg: 750 mg
>100 kg: 1000 mg

Subcutaneously: 125 mg once weekly.

For juvenile idiopathic arthritis:
Children ≥6 years and adolescents:
IV infusion: Dosing is according to body weight. Following the initial IV infusion, repeat IV infusion at 2 weeks and 4 weeks after the initial infusion, and every 4 weeks thereafter.
<75 kg: 10 mg/kg
75-100 kg: 750 mg
>100 kg: 1000 mg

Children ≥2 years and adolescents:
Subcutaneously:
10-<25 kg: 50 mg once weekly
25-<50 kg: 87.5 mg once weekly
≥50 kg: 125 mg once weekly

What are the side effects of Abatacept?

Common side effects of Abatacept include headache, upper respiratory tract infection, nasopharyngitis, and nausea.

Who should not take Abatacept?

People who are allergic to Abatacept or any component of the formulation.

Pharmacist Tips:

– Store your new, unused medicine syringe in its original carton in the refrigerator.
– Remove one prefilled syringe from the refrigerator and wait 30 minutes to allow it to reach room temperature. Do not speed up the warming process in any way, such as using the microwave or placing the syringe in warm water. Also, do not remove the needle cover while allowing the prefilled syringe to reach room temperature.
– Each prefilled syringe is for one use only.
– Change (rotate) your injection site with each injection. Do not use the same site for each injection.
– This drug may make you more susceptible to infections. Seek medical help immediately if you have symptoms such as fever and sore throat.

Common dosing schedule:
Abatacept can be injected subcutaneously in the thigh and stomach by yourself, or upper arm by your caregiver only.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Abatacept may interact with:
– Live vaccine
– Tumour necrosis factor inhibitors, e.g. Etanercept, Infliximab
– Biologics disease-modifying anti-rheumatic drugs, e.g. Tocilizumab, Rituximab

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Abatacept in Hong Kong?

In Hong Kong, Abatacept is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Abatacept in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.