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Infliximab

Last updated on 04/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Infliximab

CHINESE NAME: 英利昔單抗

BRAND NAME(S) IN HONG KONG: Remicade

DRUG CLASS: Gastrointestinal drugs, Immunosuppressants

SUB CLASS: Monoclonal antibodies, Tumour necrosis factor inhibitor, Biologics Disease-Modifying Anti-Rheumatic drugs

USED FOR: Crohn’s disease, Moderate to severe rheumatoid arthritis, Plaque psoriasis, Psoriatic arthritis, Ulcerative colitis, Ankylosing spondylitis

AVAILABLE DOSAGE FORMS:
– 100mg (IV infusion)

What is Infliximab for?

Infliximab, which is a monoclonal antibody and biologics Disease-Modifying Anti-Rheumatic Drug (DMARDs), belongs to a class of medications called Tumour Necrosis Factor inhibitors. It works by inhibiting a substance in the body to reduce inflammation and weaken the immune system. It is used to treat Crohn’s disease, moderate-to-severe rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis.

How to use it?

Infliximab is administered through intravenous infusion. Prior to administration, you may be premedicated with antihistamines, Paracetamol, and/or corticosteroids to prevent infusion-related reactions (such as dizziness, nausea, fever, vomiting).

For Crohn’s disease in patients ≥6 years of age:
5 mg/kg at 0, 2, and 6 weeks, followed by 5 mg/kg every 8 weeks thereafter.

For moderate to severe rheumatoid arthritis:
3 mg/kg at 0, 2, and 6 weeks, followed by 3 mg/kg every 8 weeks thereafter. It has to be in combination with Methotrexate.

For plaque psoriasis:
5 mg/kg at 0, 2, and 6 weeks, followed by 5 mg/kg every 8 weeks thereafter.

For psoriatic arthritis:
5 mg/kg at 0, 2, and 6 weeks, followed by 5 mg/kg every 8 weeks thereafter. It can be used with or without Methotrexate.

For ulcerative colitis in patients ≥6 years of age:
5 mg/kg at 0, 2, and 6 weeks, followed by 5 mg/kg every 8 weeks thereafter.

For ankylosing spondylitis:
5 mg/kg at 0, 2, and 6 weeks, followed by 5 mg/kg every 6 weeks thereafter.

What are the side effects of Infliximab?

Common side effects of Infliximab include abdominal pain, nausea, headache, and infection.

Who should not take Infliximab?

– People who are allergic to Infliximab, murine proteins or any component of the formulation
– People with heart failure should be cautious in use

Pharmacist Tips:

– This drug may worsen your heart failure or develop other heart problems. Report any symptoms immediately such as shortness of breath, oedema, chest pain, and dizziness.
– This drug may cause serious liver problems. Report any symptoms immediately such as fatigue, abdominal pain, loss of appetite, itching, bruising, and yellow skin or eyes.
– This drug may make you more susceptible to serious infections during and after treatment. Seek medical help immediately if you have symptoms such as fever. sore throat, or fatigue.

Common dosing schedule:
N/A.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Infliximab may interact with:
– Live vaccine
Warfarin
– Other biologics Disease-Modifying Anti-Rheumatic Drugs, e.g. Tocilizumab, Rituximab

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Infliximab in Hong Kong?

In Hong Kong, Infliximab is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Infliximab in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.