Medicines & Supplements A to Z > Valproate Sodium

Valproate Sodium

Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Valproate Sodium

CHINESE NAME: 丙戊酸鈉

BRAND NAME(S) IN HONG KONG: Epilim 穩得寧

DRUG CLASS: Antipsychotics, Anticonvulsants

SUB CLASS: Valproic acid

USED FOR: Treatment and prevention of seizures and epilepsy, complex partial seizures, migraine prevention

AVAILABLE DOSAGE FORMS:
– 100 mg, 200 mg, 300 mg, 500 mg (tablets)
– 200 mg (enteric-coated tablets)
– 200 mg/5ml (syrups)
– 400 mg (injections)

What is Valproate Sodium for?

Valproate Sodium belongs to a class of medications called valproic acid. It works by balancing the chemicals in your brain and is therefore used for treating a wide range of seizures and epilepsy. It is also used for migraine prevention.

How to use it?

Valproate Sodium can be taken by mouth or given as injections into your veins. Oral Valproate Sodium should be taken with food.
The dosages for oral use are listed below.

All forms of epilepsy
Adult
Initially 600 mg daily in 1-2 divided doses, then increase in steps of 150-300 mg every 3 days. Maintenance dose is 1-2 g daily, alternatively 20-30 mg/kg body weight daily. Maximum dose is 2.5 g daily.
Child 12-17 years
Initially 600 mg daily in 1-2 divided doses, then increase in steps of 150-300 mg every 3 days. Maintenance dose is 1-2 g daily in 2 divided doses. Maximum dose is 2.5 g daily.
Child 1 month – 11 years
Initially 10-15 mg/kg body weight daily in 1-2 divided doses, maximum 600 mg per dose. Maintenance dose is 25-30 mg/kg body weight daily in 2 divided doses.

Prevention of migraine
Adult
Initially 200 mg twice daily, then increase if necessary to 1.2-1.5 g daily in divided doses.

What are the side effects of Valproate Sodium?

Common side effects of Valproate Sodium include abdominal pain, agitation, nausea and vomiting, hair loss, regrowth with curly hair, difficulty concentrating, confusion, diarrhoea, drowsiness, hallucination, headache and memory loss.

Who should not take Valproate Sodium?

– People allergic to Valproate Sodium or any component of the formulation
– Patients with reduced liver function or liver failure
– Patients with urea cycle disorders or mitochondrial disorders
Pregnant women and those who are trying to get pregnant

Pharmacist Tips:

– If you are a woman of childbearing potential, avoid getting pregnant during therapy and use effective contraception.
– This medication can make you dizzy. Avoid driving or operating machinery until you know how you respond to Valproate Sodium.
– Do not stop the medication without discussing it with your doctor first.
– Avoid alcohol while taking this medication.

Common dosing schedule:
Valproate Sodium is taken once or twice daily. It should be taken with food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Valproate Sodium may interact with:
– Anticonvulsants, e.g. Phenobarbital, Phenytoin
– Salicylates, e.g. Aspirin
– Benzodiazepines, e.g. Lorazepam, Midazolam
– Monoamine oxidase inhibitors (MAOIs), e.g. Isocarboxazid, Selegiline
– Antipsychotics, e.g. Aripiprazole, Risperidone, Olanzapine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Valproate Sodium in Hong Kong?

In Hong Kong, Valproate Sodium is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Valproate Sodium in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.