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Urokinase

Last updated on 16/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Urokinase

ALTERNATIVE NAME: uPA

CHINESE NAME: 尿激酶

BRAND NAME(S) IN HONG KONG: /

DRUG CLASS: Fibrinolytics

SUB CLASS: Tissue plasminogen activator (tPA)

USED FOR: Pulmonary embolism, Treatment of venous thromboembolism (VTE)

AVAILABLE DOSAGE FORMS: 60000IU (injections)

What is Urokinase for?

Alteplase belongs to a class of medications called tissue plasminogen activators (tPA). There are a lot of severe conditions which involve insufficient oxygen to body parts, such as pulmonary embolism (blocked vessel in lungs) and venous thromboembolism (blocked veins). Tissue plasminogen activators can dissolve blood clots quickly to decongest blocked blood vessels. It is considered as an emergency medication for patients in hospitals. However, there are contraindications that limit many patients from using Alteplase and other fibrinolytics.

How to use it?

Urokinase is available as injections which will be injected into a vein in hospitals. The usual dose is 4400 units/kg infused over 10-20 minutes, followed by 4400 units/kg/hour for 12-24 hours.

What are the side effects of Urokinase?

Common side effects of Urokinase include anaphylactic reaction, hemorrhage, fever, edema and hypotension.

Who should not take Urokinase?

– People who are allergic to Alteplase or any component in the formulation
– People with a prior ischemic stroke or severe head trauma within 3 months
– Patients with bleeding disorder
– People with gastric bleeding within 1 month
– Patients with history of intracranial or spinal surgery within 3 months
– Patients with current intracranial bleeding

Pharmacist Tips:

– This drug may cause you to bleed more easily, so best to avoid injury. Also report any signs of unusual bleeding, such as bruising, non-stop nose bleeding, or coughing blood.
– Patients with pulmonary embolism and VTE often require taking other medications to prevent blood clotting and other cardiovascular events for long term.

Common dosing schedule:
N/A.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Urokinase may interact with:
– Angiotensin-converting enzyme inhibitors, e.g. Captopril, Lisinopril
– Anticoagulants, e.g. Warfarin, Edoxaban, Dabigatran
– Antiplatelets, e.g. Dipyridamole, Aspirin, Clopidogrel
– Nonsteroidal anti-inflammatory drugs, e.g. Ibuprofen, Diclofenac
– Selective serotonin reuptake Inhibitors (SSRIs), e.g. Fluoxetine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Urokinase in Hong Kong?

In Hong Kong, Urokinase is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Urokinase in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.