Alteplase belongs to a class of medications called tissue plasminogen activators (tPA). There are a lot of severe conditions which involve insufficient oxygen to body parts, such as pulmonary embolism (blocked vessel in lungs) and venous thromboembolism (blocked veins). Tissue plasminogen activators can dissolve blood clots quickly to decongest blocked blood vessels. It is considered as an emergency medication for patients in hospitals. However, there are contraindications that limit many patients from using Alteplase and other fibrinolytics.
Urokinase is available as injections which will be injected into a vein in hospitals. The usual dose is 4400 units/kg infused over 10-20 minutes, followed by 4400 units/kg/hour for 12-24 hours.
Common side effects of Urokinase include anaphylactic reaction, hemorrhage, fever, edema and hypotension.
Common dosing schedule:
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Urokinase may interact with:
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
In Hong Kong, Urokinase is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Urokinase in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.