Medicines & Supplements A to Z > Trazodone


Last updated on 18/03/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  



BRAND NAME(S) IN HONG KONG: Mesyrel, Trazopress, Trittico

DRUG CLASS: Antidepressant; Serotonin Antagonist and Reuptake Inhibitor 

USED FOR: Depression, anxiety 

OTHER DRUGS IN THE SAME CLASS: Citalopram, Desvenlafaxine, Duloxetine, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine

– 50mg, 75mg, 100mg (tablets)
– 75mg, 150mg (prolonged-release tablets)

What is Trazodone for?

Trazodone is an antidepressant that works by balancing different chemicals in your brain to improve your mood. Trazodone is therefore used to treat depression. Because of its sedating effects it is also used for insomnia and in people with dementia who are agitated.

How to use it?

Trazodone can be taken by mouth as conventional tablets or prolonged release tablets. For prolonged release tablets, they cannot be chewed or crushed so you need to swallow whole. 

If you are taking it to treat depression, you should start with 150 mg (or 100 mg for elderly) daily after food in divided doses or 150 mg (or 100 mg for elderly) once daily at bedtime. The dose can be increased to 300 mg daily or 600 mg daily in divided doses if necessary. When used for insomnia, starting doses range from 12.5 to 100 mg at bedtime.

What are the side effects of Trazodone? 

Common side effects of Trazodone include diarrhoea, drowsiness, dizziness, fatigue, nausea and vomiting, blurred vision, weight changes, dry mouth, stuffy nose, constipation, headache, and sexual dysfunction.

Who should not take Trazodone?

– People allergic to Trazodone or any ingredient of the formulation
– People who are taking monoamine oxidase (MAO) inhibitors or have taken them within the past 14 days

Pharmacist Tips:

– Trazodone can cause serotonin syndrome if taken together with selective serotonin reuptake inhibitors (SSRI), serotonin-norepinephrine reuptake inhibitors (SNRI), triptans, Tramadol, Lithium, and St John’s Wort. Symptoms include agitation, increased heartbeat, quick involuntary muscle twitching, and sweating. Stop taking the medicine and seek immediate medical attention if you suspect serotonin syndrome.
– Do not discontinue Trazodone abruptly. Always discuss with your doctor or pharmacist. 

Common dosing schedule:
Take Trazodone after a meal or light snack.

If it is an extended-release preparation, take it on an empty stomach. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Trazodone may interact with:
– Antidepressants, e.g. Amitriptyline, Fluoxetine
– Antifungal agents, e.g. Ketoconazole, Itraconazole
– Antiepileptics, e.g. Carbamazepine, Phenytoin 

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Trazodone in Hong Kong?

In Hong Kong, Trazodone is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Trazodone in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.