Medicines & Supplements A to Z > Stalevo

Stalevo

Last updated on 13/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Levodopa + Carbidopa + Entacapone 

CHINESE NAME: 左旋多巴+卡比多巴+恩他卡(Stalevo)

DRUG CLASS: Antiparkinsonian agents

SUB CLASS: Dopamine precursor, Decarboxylase inhibitors, COMT inhibitors

USED FOR: Parkinson’s disease

AVAILABLE DOSAGE FORMS: 50mg/12.5mg/200mg, 75mg/18.75mg/200mg, 100mg/25mg/200mg, 125mg/31.25mg/200mg, 150mg/37.5mg/200mg, 200mg/50mg/200mg (tablets)

What is Stalevo for?

Stalevo is a combination of three antiparkinsonian agents. The function of Levodopa, which is a dopamine precursor, is enhanced in the brain by both Carbidopa and Entacaopone in the way of preventing the breakdown of Levodopa. It is indicated for the treatment of Parkinson’s disease.

How to use it?

Stalevo is taken orally as a tablet. It should be a substitute for patients already stabilized on Levodopa/Carbidopa, and dose should be individualized based on therapeutic response. 

Generally, the maximum daily dose of Stalevo 50-150 (Levodopa dose) is 8 tablets, while Stalevo 200 is 6 tablets. Swallow tablet whole. Do not crush, break, or chew.

What are the side effects of Stalevo?

Common side effects include dyskinesias, diarrhea, nausea, abdominal pain, vomiting, or dry mouth.

Who should not take Stalevo?

Patients with narrow angle glaucoma

Pharmacist Tips:

– Avoid driving or operating machinery until you know how you respond to Stalevo as it may cause drowsiness.
– Avoid drinking alcohol during the treatment.
– It may take a few months to see the full effect.
– Do not stop taking Stalevo suddenly as it may cause a serious side effect.
– A dark color (red, brown, or black) may show up in your saliva, urine, or sweat. This is not harmful but may discolor your clothes.
– This drug may “wear off” as the time for your next dose gets closer. Tell your doctor if this happens and it bothers you.

Common dosing schedule:
Stalevo can be taken with or without food, but be careful not to have a change in diet to high-fat or high-calorie foods as this may delay absorption.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Stalevo may interact with:
Phenytoin
Warfarin
Probenecid
– Iron salts or multivitamins containing iron salts
– Dopamine antagonists, e.g. Metoclopramide, Domperidone
– Tricyclic antidepressants, e.g. Amitriptyline, Doxepin
– Antibiotics, e.g. Rifampicin, Erythromycin, Ampicillin
– Antipsychotics, e.g. Risperidone, Olanzapine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Stalevo in Hong Kong?

In Hong Kong, Stalevo is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Stalevo in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.