Medicines & Supplements A to Z > Somatostatin


Last updated on 03/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Somatostatin



DRUG CLASS: Endocrine drugs

SUB CLASS: Hormones

USED FOR: Gastrointestinal bleeding, Variceal bleeding, Prophylaxis and treatment of surgery complications, Fistulas

– 3mg (injections)

What is Somatostatin for?

Somatostatin is a synthetic hormone. It mimics our natural hormones to regulate the endocrine system and control gastrointestinal motility as well as visceral bleeding. It is used to treat upper gastrointestinal bleeding, esophageal varices bleeding, and fistulas (intestinal, biliary, or pancreatic). It is also indicated for prophylaxis and treatment of postoperative complications following pancreatic surgery.

How to use it?

Somatostatin is injected intravenously as bolus or infusion.

For upper gastrointestinal bleeding:
250 mcg bolus administered over 3-5 minutes, immediately followed by 250 mcg/hour as continuous infusion. Continue 48-72 hours after the bleeding has stopped to avoid rebleeding.

For esophageal varices bleeding:
250 mcg bolus administered over 3-5 minutes, immediately followed by 250-500 mcg/hour as a continuous infusion for 2-5 days.

For intestinal, biliary, or pancreatic fistulas:
250 mcg/hour as a continuous infusion. Continue until fistula closure, then decrease to 125 mcg/hour for 48 hours to avoid recurrence.

For prophylaxis and treatment of postoperative complications following pancreatic surgery:
250 mcg/hour as a continuous infusion starting prior to surgery and continued for 5 days.

What are the side effects of Somatostatin?

Common side effects of Somatostatin include abnormal blood pressure, diarrhea, nausea, vomiting, and flushing.

Who should not take Somatostatin?

– People who are allergic to Somatostatin or any component of the formulation
– Pregnant or breastfeeding women

Pharmacist Tips:

This drug may increase your blood glucose level. Report any symptoms immediately such as confusion, feeling sleepy, more thirst or more hungry. 

Common dosing schedule:

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Somatostatin may interact with:
– Antidiabetics drugs, e.g. Metformin, Pioglitazone

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Somatostatin in Hong Kong?

In Hong Kong, Somatostatin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Somatostatin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.