> Western Medicines > Sirolimus

Sirolimus

Used for: Treatment of lymphangioleiomyomatosis, Prophylaxis of organ transplant rejections
Chinese name:

What is Sirolimus for?

Sirolimus is an immunosuppressant inhibiting a regulatory kinase mTOR to lower the activity of T-lymphocytes and hence the immune system. Sirolimus is used for the treatment of lymphangioleiomyomatosis and prophylaxis and treatment of organ transplant rejections.

How to use it?

Sirolimus is administered as oral tablets in Hong Kong. It should not be split, chewed or crushed. It does not differ much whether it is taken with or without food. When it is used for a kidney transplant, it should be used 4 hours after oral Cyclosporin. Listed below are the indications and the dosages.

 

Lymphangioleiomyomatosis
Adult and elderly
The initial dose is 2 mg once daily. Adjust the dose to maintain a target concentration of 5-15 ng/mL by obtaining the trough concentration after 10-20 days.

 

Prophylaxis of rejection in kidney transplant
Administered with Cyclosporin and corticosteroids.
Adult and elderly
Low to moderate immunological risk: The loading dose is 6 mg on day 1 after transplantation. The maintenance dose is 2 mg once daily. Adjust the dose to maintain a target trough concentration of 4-12 ng/mL with the Cyclosporin and corticosteroids dose tapered down. After 2-3 months, the concentration should become 12-20 ng/mL with Cyclosporin being stopped in 4-8 weeks.
High immunological risk: The loading dose is 15 mg on day 1 after transplantation. The maintenance dose is 5 mg once daily for a year. Dose adjusted based on body response.

 

Child above 13 years of age and lighter than 40 kg
The loading dose is 3 mg/m2 on day 1 after transplantation. The maintenance dose is 1 mg/m2 once daily. Dose adjusted based on body response.

What are the side effects of Sirolimus?

Common side effects of Sirolimus include peripheral oedema, hypertension, headache, acne, skin rash, high blood lipid, constipation, urinary tract infection, anaemia, infection, muscle pain and increased blood creatinine.

Who should not take Sirolimus?

  • People who are allergic to Sirolimus or any component of the formulation.
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Where to buy Sirolimus in Hong Kong?

In Hong Kong, Sirolimus is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

 

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Sirolimus in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.

Brands in Hong Kong
Rapamune
Available dosage
  • 0.5mg / 1mg (Tablets)
Drug class
Immunosuppressants
Sub class
MTOR Inhibitors
Other drugs in same class
Everolimus
Used for: Treatment of breast cancer, Targeted cancer therapy, Tuberous sclerosis complex-associated partial-onset seizures, Prophylaxis of organ transplant rejections
Chinese name: