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Rasburicase

Last updated on 15/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Rasburicase

CHINESE NAME: 拉布立酶

BRAND NAME(S) IN HONG KONG: Fasturtec 法舒克

DRUG CLASS: Endocrine Drugs

SUB CLASS: Enzymes

USED FOR: Hyperuricemia associated with malignancy

AVAILABLE DOSAGE FORMS:
– 1.5 mg (injections)

What is Rasburicase for?

Rasburicase belongs to the class of endocrine drugs. It is an enzyme converting uric acid to allantoin for the purpose of treating hyperuricemia with malignancy.

How to use it?

Rasburicase is only available as intravenous injections in Hong Kong with no filter and as an infusion, but not bolus. Your doctor will advise you on the dosage and frequency depending on the risk of your hyperuricemia.

Hyperuricemia associated with malignancy
Infant, Child, Adolescent, Adult and Elderly
0.05-0.2 mg/kg once daily for 1-7 days.

What are the side effects of Rasburicase?

Common side effects of Rasburicase include, but not limited to, peripheral edema, anxiety, rash, nausea, vomiting, headache, hyperbilirubinemia and fever.

Who should not take Rasburicase?

– People who are allergic to Rasburicase or any component of the formulation
– People with a history of hemolytic reaction or methemoglobinemia associated with rasburicase
– Patients with glucose-6-phosphatase dehydrogenase (G6PD) deficiency

Pharmacist Tips:

– Rasburicase should not be an IV bolus
– Rasburicase should not be filtered during administration
– Avoid dietary intake of high purine foods 

Common dosing schedule:
Rasburicase is to be injected once daily through the veins by healthcare professionals.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Rasburicase may interact with:
– Topical Dapsone
– Local anesthetics, e.g. Lignocaine, Prilocaine, Bupivacaine
– Nitric Oxide
– Sodium Nitrite

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Rasburicase in Hong Kong?

In Hong Kong, Rasburicase is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Rasburicase in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.