Medicines & Supplements A to Z > Propylthiouracil


Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Propylthiouracil




DRUG CLASS: Endocrine drugs

SUB CLASS: Thioamides

USED FOR: Hyperthyroidism


What is Propylthiouracil for?

Propylthiouracil is a type of thioamide antithyroid agent. It works by reducing the level of thyroid hormone produced and secreted to treat hyperthyroidism in patients with Graves’ disease who are intolerant of Methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option.

How to use it?

Propylthiouracil is taken orally as tablets. 

Initial dose: depending on the severity, 200-400 mg daily divided into three doses.
Maintenance dose: 50-150mg daily divided into two to three doses.

What are the side effects of Propylthiouracil?

Common side effects of Propylthiouracil include bitter taste, rash, arthralgias, and fever.

Who should not take Propylthiouracil?

People who are allergic to Propylthiouracil or any component of the formulation.

Pharmacist Tips:

– Do not drive or operate machinery until you know the effect of the medicine.
– This drug may cause serious blood side effects. Report any symptoms such as fever or sore throat immediately, and have regular blood tests.
– This drug may cause serious liver problems. Report any symptoms immediately such as fatigue, abdominal pain, loss of appetite, itching, bruising, and yellow skin or eyes.
– Tell your doctor if you are pregnant or planning to get pregnant before using this drug. 

Common dosing schedule:
Propylthiouracil can be taken with or without food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Propylthiouracil may interact with:
– Beta-blockers, e.g. Propranolol, Metoprolol

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Propylthiouracil in Hong Kong?

In Hong Kong, Propylthiouracil is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Propylthiouracil in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.