Medicines & Supplements A to Z > Propofol


Last updated on 30/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  




DRUG CLASS: Sedatives

SUB CLASS: Anesthetic agents

USED FOR: General anesthesia, Sedation

AVAILABLE DOSAGE FORMS: 1%, 2% (injections)

What is Propofol for?

Propofol is a short-acting anesthetic. It works by suppressing the central nervous system for general anesthesia and sedation.

How to use it?

Propofol is injected intravenously. 

For general anesthesia:
Doses should be individualized by healthcare professionals.

For sedation of mechanically ventilated patients in the ICU:
5 mcg/kg/min intravenous infusion for 5 minutes, and then slowly titrated up to a maintenance dose of 5-50 mcg/kg/min.

For monitored anesthesia care sedation:
Doses should be individualized by healthcare professionals.

What are the side effects of Propofol?

Common side effects include injection site pain and burning sensation, involuntary muscle movements, hypotension, aponea, nausea and vomiting.

Who should not take Propofol?

– People who are allergic to Propofol, eggs, egg products, soybeans, soy products, or any component of the formulation
– People contraindicated to general anesthesia and sedation

Pharmacist Tips:

– If you experience any addiction under supervision, notify your medical professionals.
– Avoid drinking and driving or operating machinery until the effects of this drug wear off and you feel fully awake.

Common dosing schedule:

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Propofol may interact with:
– Anesthetic, e.g. Isoflurane, Halothane
– Sedatives, e.g. Phenobarbital, Zolpidem
– Antihypertensives, e.g. Metoprolol, Verapamil, Frusemide
– Opioids, e.g. Tramadol, Morphine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Propofol in Hong Kong?

In Hong Kong, Propofol is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Propofol in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.