Medicines & Supplements A to Z > Prolia


Last updated on 13/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  



DRUG CLASS: Antiresorptive agents

SUB CLASS: Monoclonal antibodies, RANKL inhibitor

USED FOR: Osteoporosis

AVAILABLE DOSAGE FORMS: 60mg/ml (injections)

What is Prolia for?

Prolia, which is a monoclonal antibody, belongs to a class of medications called RANKL inhibitors. It works by inhibiting a substance in your body to decrease the breakdown of the bone. It is indicated for the treatment of osteoporosis and bone loss in high-risk patients.

How to use it?

Prolia is injected subcutaneously by a healthcare professional. The usual dose is 60 mg once every 6 months. Also, dietary supplements of Calcium 1000 mg daily and Vitamin D ≥400 units daily are recommended.

What are the side effects of Prolia?

Common side effects of Prolia include back pain, arthralgia, hypercholesterolemia, musculoskeletal pain, nasopharyngitis, and skin problems.

Who should not take Prolia?

– People who are allergic to Denosumab or any component of the formulation
Pregnant women
– Patients with pre-existing hypocalcemia must be corrected prior to initiating therapy

Pharmacist Tips:

– You will have a dental exam before starting this drug. Take good care of your teeth and see a dentist often during treatment.
– This drug may make you more susceptible to infections. Seek medical help immediately if you have symptoms such as high fever, shortness of breath, abdominal pain, and pain in passing urine.

Common dosing schedule:
Prolia should be administered every 6 months, subcutaneously in the upper arm, upper thigh, or abdomen.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Prolia may interact with:
– Steroids, e.g. Prednisone
– Immunosuppressants, e.g. Tacrolimus, Cyclosporin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Prolia in Hong Kong?

In Hong Kong, Prolia is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Prolia in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.