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Probenecid

Last updated on 09/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Probenecid

CHINESE NAME: 丙磺舒

BRAND NAME(S) IN HONG KONG: U-Acid

DRUG CLASS: Antigout agents

SUB CLASS: Uricosuric agents

USED FOR: Gout, Hyperuricaemia

AVAILABLE DOSAGE FORMS:
– 500 mg (tablets)

What is Probenecid for?

Probenecid belongs to a class of medications called uricosuric agents. It promotes the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. It is used to treat hyperuricaemia and gout.

How to use it?

Probenecid is available as a tablet which should be taken with food. Drink plenty of water (2-3 litres per day) to ensure efficient elimination of uric acid via urine.

Hyperuricaemia with gout
Adult
250 mg twice daily for 1 week, followed by 500 mg twice daily thereafter. Increase up to 2 g daily by increments 500 mg every 4 weeks if needed.

Adjunct to antibacterial therapy
Adult
500 mg 4 times daily.
Child over 2 years
Body weight <50 kg: Initially, 25 mg/kg body weight in 4 divided doses, followed by 40 mg/kg body weight in 4 divided doses.

What are the side effects of Probenecid?

Common side effects of Probenecid include anorexia, nausea and vomiting, and headache.

Who should not take Probenecid?

– People allergic to Probenecid or any component of the formulation.
– Children under 2 years.
– Patients who are currently taking salicylates.
– Patients with uric acid kidney stones.
– Patients with any blood disorders.

Pharmacist Tips:

– This drug may cause false-positive results when using urine glucose testing products in diabetic patients.
– Maintain adequate fluid intake (2-3 litres per day) to prevent kidney stone formation.
– You may take Probenecid with food, milk or antacids to minimize gastric irritation.
– You should avoid taking salicylates while using Probenecid.

Common dosing schedule:
Probenecid is usually administered every 12 hours in the treatment of hyperuricaemia and gout.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Probenecid may interact with:
– Salicylates
– Methotrexate
– Sulfonamides
– Non-steroidal anti-inflammatory drugs, e.g. Ibuprofen, Naproxen, Mefenamic Acid

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Probenecid in Hong Kong?

In Hong Kong, Probenecid is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Probenecid in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.