Medicines & Supplements A to Z > Pravastatin
Last updated on 24/03/2021.
GENERIC NAME: Pravastatin
CHINESE NAME: 普伐他汀
BRAND NAME(S) IN HONG KONG: Apo-Pravastatin, PMS-Pravastatin, Pravinat
DRUG CLASS: HMG-CoA reductase inhibitor; Cholesterol lowering drug
USED FOR: Elevated blood lipids, prevention of cardiovascular events
What is Pravastatin for?
Pravastatin is a cholesterol lowering drug that works like Atorvastatin, which is primarily by blocking the enzyme involved in cholesterol synthesis, especially in the liver, and hence reduces cholesterol levels. It is the first-line medication used for hypercholesterolaemia or hyperlipidemia (elevated blood cholesterol).
The detailed indications of Pravastatin include:
– Primary hypercholesterolemia or combined (mixed) hyperlipidemia in patients who did not respond adequately to diet and other appropriate measures
– Heterozygous familial hypercholesterolemia in patients who have not responded adequately to diet and other appropriate measures
– Prevention of cardiovascular events in patients with cardiovascular disease or at high risk of having a cardiovascular event (e.g. people who smoke, people with diabetes).
How to use it?
Pravastatin is available as tablets to be taken orally, and is often combined with sodium salts. The adult dose range of Pravastatin is 10 to 40 mg once daily. The maximum daily dose is 80 mg per day. The dose of Pravastatin is adjusted based on your cholesterol level by your doctor at least every 4 weeks. Usually, a lower dose is used in Asian population.
What are the side effects of Pravastatin?
The most common side effects of Pravastatin are muscle pain, muscle weakness, and shoulder pain. Rare side effects include an increased risk of diabetes, cognitive impairment (inability to focus or remember) and rhabdomyolysis (severe muscle breakdown).
Who should not take Pravastatin?
– Patients with active liver disease
– People allergic to Pravastatin or other ingredients of formulation
– Pregnant or breastfeeding women, or those who plan to become pregnant
– Seek medical attention immediately if there is any unexplained muscle pain.
– Take adequate contraception during and 1 month after therapy if you are a female patient with childbearing potential.
– Avoid consumption of large amounts of grapefruit and grapefruit juice while you are on this medication.
– Reductions in blood cholesterol will be the best when Pravastatin is used with diet and exercise
Common dosing schedule:
You can take Pravastatin once a day with or without food usually in the evening. Take the drug at the same time every day.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Pravastatin may interact with:
– Antifungal agents, e.g. Itraconazole, Ketoconazole, Posaconazole
– Protease inhibitors, e.g. Boceprevir, Telaprevir
– Red yeast rice
– Some antibiotics, e.g. Clarithromycin, Erythromycin
– St John’s Wort
Where to buy Pravastatin in Hong Kong?
In Hong Kong, Pravastatin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at http://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Pravastatin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.