Pramipexole belongs to a class of medications called dopamine agonists. It works in the same way as dopamine on the nervous system to control body movements. Therefore, it can be used to treat Parkinson’s disease and restless leg syndrome (conventional tablets only).
Pramipexole can be taken orally as conventional tablets or prolonged-release tablets, which should be swallowed whole without breaking or cutting. Listed below are the indications and the dosages, which patients with poor renal function may need a lower dose.
For Parkinson’s disease:
Initial: 0.125 mg three times daily for 1 week, and increase the dose as follows if needed (use the lowest effective dose):
week 2: 0.25 mg three times daily
week 3: 0.5 mg three times daily
week 4: 0.75 mg three times daily
week 5: 1 mg three times daily
week 6: 1.25 mg three times daily
week 7: 1.5 mg three times daily
Usual maintenance dose: 0.5-1.5 mg three times daily
Initial: 0.375 mg once daily, and can be increased to 0.75 mg after the first week, then increase in 0.75 mg increments thereafter.
Usual maintenance dose: 1.5-4.5 mg once daily
For restless leg syndrome:
Initial: 0.125 mg once daily 2-3 hours before bedtime for the first 4-7 days, and increase the dose as follows if needed (use the lowest effective dose):
second 4-7 days: 0.25 mg once daily 2-3 hours before bedtime
third 4-7 days: 0.5 mg once daily 2-3 hours before bedtime
Common dosing schedule:
Pramipexole can be taken with or without food. For restless leg syndrome, it should be taken 2-3 hours before bedtime.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Pramipexole may interact with:
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
In Hong Kong, Pramipexole is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Pramipexole in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.
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