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Pramipexole

Last updated on 13/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Pramipexole

CHINESE NAME: 普拉克索

BRAND NAME(S) IN HONG KONG: Mirapex/Mirapex ER 妙樂柏

DRUG CLASS: Antiparkinsonian agents

SUB CLASS: Dopamine agonists

USED FOR: Restless leg syndrome, Parkinson’s disease

AVAILABLE DOSAGE FORMS:
– 0.375mg, 0.75mg, 1.5mg (prolonged-release tablets)
– 0.25mg, 0.5mg, 1mg, 1.5mg (tablets)

What is Pramipexole for?

Pramipexole belongs to a class of medications called dopamine agonists. It works in the same way as dopamine on the nervous system to control body movements. Therefore, it can be used to treat Parkinson’s disease and restless leg syndrome (conventional tablets only).

How to use it?

Pramipexole can be taken orally as conventional tablets or prolonged-release tablets, which should be swallowed whole without breaking or cutting. Listed below are the indications and the dosages, which patients with poor renal function may need a lower dose. 

For Parkinson’s disease:
Conventional tablets:
Initial: 0.125 mg three times daily for 1 week, and increase the dose as following if needed (use the lowest effective dose):
week 2: 0.25 mg three times daily
week 3: 0.5 mg three times daily
week 4: 0.75 mg three times daily
week 5: 1 mg three times daily
week 6: 1.25 mg three times daily
week 7: 1.5 mg three times daily

Usual maintenance dose: 0.5-1.5 mg three times daily

Prolonged-release tablets:
Initial: 0.375 mg once daily, and can be increased to 0.75 mg after the first week, then increase in 0.75 mg increments thereafter.
Usual maintenance dose: 1.5-4.5 mg once daily

For restless leg syndrome:
Conventional tablets:
Initial: 0.125 mg once daily 2-3 hours before bedtime for first 4-7 days, and increase the dose as following if needed (use the lowest effective dose):
second 4-7 days: 0.25 mg once daily 2-3 hours before bedtime
third 4-7 days: 0.5 mg once daily 2-3 hours before bedtime

What are the side effects of Pramipexole?

Common side effects of Pramipexole include orthostatic hypotension, constipation, nausea, dizziness, abnormal dream, extrapyramidal movements, insomnia, and hallucinations.

Who should not take Pramipexole?

People who are allergic to Pramipexole or any component of the formulation.

Pharmacist Tips:

– Avoid driving or operating machinery until you know how you respond to Pramipexole as it may cause drowsiness.
– Avoid drinking alcohol during the treatment.
– Do not stop taking Pramipexole suddenly as it may worsen your symptoms.
– Some people taking this drug have fallen asleep during activities like driving, eating, or talking, and they did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after this drug was started. Immediately report the occurrence of falling asleep during activities of daily living.
– Some people may develop strong urges, such as gambling, compulsive eating, compulsive buying, and increased sex drive. If you or people around you notice that you are developing unusual behaviors, talk to your doctor.

Common dosing schedule:
Pramipexole can be taken with or without food. For restless leg syndrome, it should be taken 2-3 hours before bedtime. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Pramipexole may interact with:
Cimetidine
Promethazine
– Calcium channel blockers, e.g. Verapamil, Diltiazem
– Dopamine antagonists, e.g. Metoclopramide, Domperidone
– Antipsychotics, e.g. Haloperidol, Olanzapine, Chlorpromazine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Pramipexole in Hong Kong?

In Hong Kong, Pramipexole is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Pramipexole in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.