Medicines & Supplements A to Z > Perampanel

Perampanel

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Perampanel

CHINESE NAME: 吡侖帕奈

BRAND NAME(S) IN HONG KONG: Fycompa 癲控達

DRUG CLASS: Anticonvulsants

SUB CLASS: Glutamate Antagonists

USED FOR: Partial seizures, Primary generalized tonic-clonic seizures

AVAILABLE DOSAGE FORMS:
– 2mg, 4mg, 6mg, 8mg, 10mg, 12mg (tablets)

What is Perampanel for?

Perampanel belongs to a class of medication called AMPA glutamate antagonists. It works by regulating a substance in the brain to alter its function. It is used for the treatment of partial seizure and primary generalized tonic-clonic seizures.

How to use it?

Perampanel is taken orally as tablets. The dose would be different if you use concomitant with some antiepileptics, such as Phenytoin, Carbamazepine, or Oxcarbazepine. 

Partial onset seizure:
Patients 4 years of age and older, without using other antiepileptic drugs:
Initial: 2 mg once daily at bedtime, and can be increased by 2 mg once daily no more frequently than once weekly based on response and tolerability.
Maintenance: 8-12 mg once daily at bedtime.

Patients 4 years of age and older, concomitant using other antiepileptic drugs:
Initial: 4 mg once daily at bedtime, and can be increased by 2 mg once daily no more frequently than once weekly based on response and tolerability.
Maintenance: not established, but shown to work as 12 mg once daily. 

Primary generalized tonic-clonic seizures:
Patients 12 years of age and older, without using other antiepileptic drugs:
Initial: 2 mg once daily at bedtime, and can be increased by 2 mg once daily no more frequently than once weekly based on response and tolerability.
Maintenance: 8 mg once daily at bedtime, up to maximum 12 mg once daily.

Patients 12 years of age and older, concomitant using other antiepileptic drugs:
Initial: 4 mg once daily at bedtime, and can be increased by 2 mg once daily no more frequently than once weekly based on response and tolerability.
Maintenance: not established, but shown to work as 12 mg once daily.

What are the side effects of Perampanel?

Common side effects of Perampanel include dizziness, somnolence, fatigue, nausea, weight gain, vertigo, headache, vomiting, abdominal pain, and anxiety.

Who should not take Perampanel?

People who are allergic to Perampanel or any component of the formulation.

Pharmacist Tips:

– Do not stop taking Perampanel suddenly as it can cause seizures.
– Do not drive or operate machinery until you know the effect of the medicine.
– Avoid drinking alcohol while taking this medicine as it may make you sleepy or dizzy.

Common dosing schedule:
Perampanel should be taken at bedtime, independently of meals

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Perampanel may interact with:
– Rifampin
– St. John’s wort
– Hypnotics, e.g. Zolpidem, Zopiclone
– Contraceptives, e.g. Levonorgestrel
– Antiepileptics, e.g. Carbamazepine, Phenytoin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Perampanel in Hong Kong?

In Hong Kong, Perampanel is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Perampanel in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.