Pemetrexed is an antifolate that inhibits enzymes thymidylate synthase, dihydrofolate reductase, GARFT, AICARFT and other enzymes to suppress the synthesis of DNA and thus cell growth. Therefore, it can be used in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.
Pemetrexed is to be injected into the veins over 10 minutes prior to the administration of platinum and after pembrolizumab if given on the same day.
Malignant pleural mesothelioma
Adult and elderly
500 mg/m2 on day 1 of each 21-day cycle together with cisplatin for 4-6 cycles, or until disease progression or unacceptable toxicity.
Non-small cell lung cancer
Adult and elderly
500 mg/m2 on day 1 of each 21-day cycle, possible with other agents including pembrolizumab, carboplatin or cisplatin. Doses are individualised based on its toxicity to blood.
Common dosing schedule:
Pemetrexed injections are prescribed in institutions by the physicians as a 21-day cycle.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Pemetrexed may interact with:
Pemetrexed may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
In Hong Kong, Pemetrexed is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Pemetrexed in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.