Medicines & Supplements A to Z > Oxcarbazepine

Oxcarbazepine

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Oxcarbazepine

CHINESE NAME: 奥卡西平

BRAND NAME(S) IN HONG KONG: Trileptal 除癲達

DRUG CLASS: Anticonvulsants

SUB CLASS: Sodium Channel Blocker

USED FOR: Partial seizures

AVAILABLE DOSAGE FORMS:
– 300mg, 600mg (tablets)
– 60mg/ml (suspension)

What is Oxcarbazepine for?

Oxcarbazepine belongs to a class of medication called sodium channel blockers. It works by stabilizing the excessive electrical activity in the brain to treat partial seizures.

How to use it?

Oxcarbazepine can be administered orally as tablets and suspension. 

Patients 17 years of age and older (monotherapy):
The usual initial dose is 300 mg twice daily, and can be increased in 300 mg/day increments every third day to a maintenance dose of 1200 mg/day.

Patients 17 years of age and older (adjunctive therapy):
The usual initial dose is 300 mg twice daily, and can be increased in 600 mg/day increments at weekly intervals to a maintenance dose of 1200 mg/day.

Pediatrics patients 4 – 16 years (monotherapy):
The usual initial dose is 8-10 mg/kg/day given in two divided doses, and can be increased in 5 mg/kg/day increments every third day to a maintenance dose of by weight as follow:

20 – <25 kg: 600-900 mg/day in 2 divided doses.
25 – <35 kg: 900-1,200 mg/day in 2 divided doses.
35 – <45 kg: 900-1,500 mg/day in 2 divided doses.
45 – <50 kg: 1,200-1,500 mg/day in 2 divided doses.
50 – <60 kg: 1,200-1,800 mg/day in 2 divided doses.
60 – <70 kg: 1,200-2,100 mg/day in 2 divided doses.
≥ 70 kg: 1,500-2,100 mg/day in 2 divided doses.

Pediatrics patients 4 – 16 years (adjunctive therapy):
The usual initial dose is 8-10 mg/kg/day given in two divided doses, of which the total dose should not exceed 600 mg/day. Slowly increase the dose, and the maintenance dose should be achieved over 2 weeks which is dependent upon patient weight:

20 – 29 kg: 900 mg once daily.
29.1 – 39 kg: 1,200 mg once daily.
> 39 kg: 1,800 mg once daily.

Pediatrics patients 2 – <4 years (adjunctive therapy):
The usual initial dose is 8-10 mg/kg/day given in two divided doses, of which the total dose should not exceed 600 mg/day. For patients under 20kg, the initial dose is 16-20 mg/kg/day given in two divided doses. Slowly increase the dose, and the maintenance dose should be achieved over 2-4 weeks which should not exceed 60 mg/kg/day in a twice-a-day regimen.

What are the side effects of Oxcarbazepine?

Common side effects of Oxcarbazepine include dizziness, somnolence, fatigue, nausea, vomiting, abnormal vision, headache, tremor, and abnormal gait.

Who should not take Oxcarbazepine?

People who are allergic to Oxcarbazepine, eslicarbazepine acetate, or any component of the formulation.

Pharmacist Tips:

– Shake the suspension bottle well before use.
– Do not stop taking Oxcarbazepine suddenly as it can cause seizures.
– Do not drive or operate machinery until you know the effect of the medicine.
– Avoid drinking alcohol while taking this medicine as it may make you sleepy or dizzy.

Common dosing schedule:
Oxcarbazepine can be taken with or without food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Oxcarbazepine may interact with:
Rifampin
St. John’s wort
– Contraceptives, e.g. Levonorgestrel
– Antiepileptics, e.g. Carbamazepine, Phenytoin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Oxcarbazepine in Hong Kong?

In Hong Kong, Oxcarbazepine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Oxcarbazepine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.