Medicines & Supplements A to Z > Oxaliplatin

Oxaliplatin

Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Oxaliplatin

CHINESE NAME: 奧沙利鉑

BRAND NAME(S) IN HONG KONG: Eloxatin 益樂鉑

DRUG CLASS: Antineoplastics

SUB CLASS: Alkylating agents

USED FOR: Cytotoxic chemotherapy, treatment of colorectal cancer

AVAILABLE DOSAGE FORMS:
– 50 mg, 100 mg (injections)

What is Oxaliplatin for?

Oxaliplatin belongs to a class of medications called alkylating agents. It stops cells from replicating and dividing by interfering with their nucleic acid function. This kills cells and inhibits the growth of malignant tumours. Oxaliplatin is used to treat cancers of the large intestine (colon) and rectum. It is used together with other anticancer medications, Fluorouracil and Folinic acid, to treat stage 3 colon cancer after surgical removal of tumour, or metastatic colon cancer (tumour that has spread to other parts of the body).

How to use it?

Oxaliplatin is injected into a vein as directed by your doctor. This process takes many hours, and you will need to rest in the hospital ward or clinic when you are on the medicine drip. Before you start using Oxaliplatin, you may be given other medicines beforehand to prevent or lessen the side effects of Oxaliplatin. The dosage of Oxaliplatin is calculated by your doctor based on your total body surface area. Your doctor will advise you on the dosage and frequency depending on your condition.

Metastatic colorectal cancer (In combination with Fluorouracil or Folinic acid)
Adult
65-85 mg per m2 body surface area given every 2 weeks for 12 cycles.

Stage III colon cancer (as adjunct therapy, in combination with Fluorouracil or Folinic acid)
Adult
75-85 mg per m2 body surface area given every 2 weeks for 12 cycles.

What are the side effects of Oxaliplatin?

Common side effects of Oxaliplatin include headache, fatigue, drowsiness, nausea, vomiting, diarrhoea, constipation, loss of appetite, stomach pain, joint or bone pain and injection site swelling or pain.

Who should not take Oxaliplatin?

– People allergic to Oxaliplatin or any component of the formulation
– Patients with reduced kidney function or kidney failure
– Patients with congenital long QT syndrome
– Patients with severe bone marrow suppression or peripheral neuropathy

Pharmacist Tips:

– This medication can cause blurred vision or drowsiness. Avoid driving or operating machinery until you know how you respond to Oxaliplatin.
– Oxaliplatin may cause tingling sensation or numbness in your fingers and toes, which may be worsened by cold temperature or any contact with cold objects. Avoid cold temperature or cold food or drinks during or within 48 hours after your treatment.
– You will need regular blood tests during Oxaliplatin treatment. Your doctor may order other tests too.
– Discuss with your doctor before taking any vaccinations as Oxaliplatin can interfere with vaccines.

Common dosing schedule:
Your doctor will advise you on the dosing schedule depending on your condition.

Some common medications Oxaliplatin may interact with:
– QT prolonging drugs, e.g. Amiodarone, Dronedarone, Amisulpride, Pimozide
– Live vaccines

Oxaliplatin may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Oxaliplatin in Hong Kong?

In Hong Kong, Oxaliplatin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Oxaliplatin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.