Obinutuzumab is a type of monoclonal antibody. It is a type of targeted therapy to treat chronic lymphocytic leukaemia (CLL) and follicular lymphoma (FL).
Obinutuzumab is infused intravenously. Premedication is required 30-60 minutes prior to treatment, including Paracetamol, an antihistamine, and either Dexamethasone or Methylprednisolone.
For previously untreated chronic lymphocytic leukaemia:
Treatment duration is 6 cycles, which one cycle consists of 28 days.
Cycle 1:
Day 1: 100 mg
Day 2: 900 mg
Day 8: 1000 mg
Day 15: 1000 mg
Cycles 2-6:
Day 1: 1000 mg every 28 days
For previously untreated follicular lymphoma:
Option 1: Treatment duration is 6 cycles, which one cycle consists of 28 days, in combination with Bendamustine.
Cycle 1:
Day 1: 1000 mg
Day 8: 1000 mg
Day 15: 1000 mg
Cycle 2-6:
Day 1: 1000 mg every 28 days
Option 2: Treatment duration is 6 cycles, which one cycle consists of 21 days, in combination with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone, followed by two additional cycles of Obinutuzumab alone.
Cycle 1:
Day 1: 1000 mg
Day 8: 1000 mg
Day 15: 1000 mg
Cycle 2-6:
Day 1: 1000 mg every 21 days
Cycle 7-8 (Obinutuzumab as monotherapy):
Day 1: 1000 mg every 21 days
Option 3: Treatment duration is 8 cycles, which one cycle consists of 21 days, in combination with Cyclophosphamide, Vincristine, and Prednisone.
Cycle 1:
Day 1: 1000 mg
Day 8: 1000 mg
Day 15: 1000 mg
Cycle 2-8:
Day 1: 1000 mg every 21 days
Option 4: For patients with stable disease, complete response, or partial response after 6 or 8 cycles of combination therapy should continue on Obinutuzumab as monotherapy for up to 2 years beginning around 2 months after the last dose of the last cycle.
– 1000 mg every 2 months for up to 2 years
For relapsed or refractory follicular lymphoma:
Option 1: Treatment duration is 6 cycles, which one cycle consists of 28 days, in combination with Bendamustine.
Cycle 1:
Day 1: 1000 mg
Day 8: 1000 mg
Day 15: 1000 mg
Cycle 2-6:
Day 1: 1000 mg every 28 days
Option 2: For patients with stable disease, complete response, or partial response after 6 cycles of combination therapy should continue on Obinutuzumab as monotherapy for up to 2 years beginning around 2 months after the last dose of the last cycle.
– 1000 mg every 2 months for up to 2 years
People who are allergic to Obinutuzumab or any component of the formulation.
Common dosing schedule:
N/A.
This schedule is for reference only, adjustments may be made according to individual needs.
Some common medications Obinutuzumab may interact with:
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
In Hong Kong, Obinutuzumab is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Obinutuzumab in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.
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