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Mycophenolate

Last updated on 21/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Mycophenolate

ALTERNATIVE NAME: Mycophenolic acid, MPA

CHINESE NAME: 黴酚酸

BRAND NAME(S) IN HONG KONG: Cellcept, Micocept, Myfortic 米芙

DRUG CLASS: Immunosuppressants

SUB CLASS: Inosine monophosphate dehydrogenase inhibitors

USED FOR: Prophylaxis of organ transplant rejections

AVAILABLE DOSAGE FORMS:
– 1 g/5ml (oral suspension)
– 500 mg (injections)
– 250 mg (capsules)
– 180 mg, 360 mg (gastro-resistant tablets)
– 500 mg (tablets)

What is Mycophenolate for?

Mycophenolate is an immunosuppressant that inhibits inosine monophosphate dehydrogenase to slow down the production of lymphocytes, hence the activity of the immune system. Mycophenolate is used for the prophylaxis of organ transplant rejections.

How to use it?

Mycophenolate is available in Hong Kong as oral capsules, tablets, gastro-resistant tablets and suspension. It can also be injected through the veins.

It does not differ much whether it is taken with or without food for adults, but for children, Micocept and Celicept should be taken on an empty stomach and Myfortic should be taken an hour before or 2 hours after meal. Myfortic should be swallowed as a whole and should not be crushed, cut, chewed no matter for children or adults. 

Listed below are the indications and the dosages.

Heart transplant
Adult and elderly
Oral or intravenous Micocept/Celicept: 1-1.5 g twice daily.

Kidney transplant
Adult and elderly
Oral or intravenous Micocept/Celicept: 0.5-1 g twice daily.
Oral Myfortic: 360-720 mg twice daily.

Infant above 3 months of age, Child
Oral suspension or intravenous Micocept/Celicept: 600 mg/m2 twice daily up to 2000 mg daily.
Oral Micocept/Celicept tablets or capsules:
– Body surface area 1.25-1.5 m2: 750 mg twice daily.
– Body surface area ≥1.5 m2: 1000 mg twice daily.

Child above 5 years of age
Oral Myfortic tablets: 400 mg/m2 twice daily up to 1440 mg daily.

Liver transplant
Adult and elderly
Oral or intravenous Micocept/Celicept: 1 g twice daily.

What are the side effects of Mycophenolate?

Common side effects of Mycophenolate include oedema, hypertension, hypotension, common bruise, skin rash, high blood glucose, constipation, urinary tract infection, anemia, increased liver enzymes, depression, cough and fever.

Who should not take Mycophenolate?

– People who are allergic to Mycophenolate mofetil, Mycophenolic acid, Mycophenolate sodium, polysorbate 80 (Tween) (for those using it intravenously) or any component of the formulation.
– Pregnant or breastfeeding women and those who intend to become pregnant.

Pharmacist Tips:

– Micocept and Celicept should not be interchanged with Myfortic.
– If a dose is missed, take one as soon as possible unless it is close to the next scheduled dose, if so, then take the next dose without doubling.
– Myfortic should be swallowed as a whole and should not be crushed, cut, chewed.

Common dosing schedule:
Mycophenolate is taken twice daily. It does not differ much whether it is taken with or without food for adults, but for children, Micocept and Celicept should be taken on an empty stomach and Myfortic should be taken an hour before or 2 hours after meal. 

Thus, for convenience, take Mycophenolate once when you just wake up and consume your breakfast an hour after, then take it once again at night before sleep at least 2 hours after dinner. Adjust your mealtime based on this.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Mycophenolate may interact with:
– Bile acid sequestrants, e.g. Cholestyramine, Colestipol, Colesevelam
– Oestrogen derivatives, e.g. Oestradiol, Ethinyloestradiol, Mestranol
– Proton pump inhibitors, e.g. Omeprazole, Esomeprazole, Pantoprazole
– Quinolones, e.g. Ciprofloxacin, Levofloxacin, Ofloxacin
– Vaccines, e.g. BCG, Smallpox and Monkeypox, COVID-19

Mycophenolate may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Mycophenolate in Hong Kong?

In Hong Kong, Mycophenolate is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Mycophenolate in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.