Medicines & Supplements A to Z > Methylprednisolone


Last updated on 03/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Methylprednisolone


BRAND NAME(S) IN HONG KONG: Advantan, Medason, Depo Medrol, Solu Medrol

DRUG CLASS: Corticosteroids

SUB CLASS: Glucocorticoids

USED FOR: Autoimmune disorders, Allergic and inflammatory disorders

– 40mg/ml (suspension for injections)
– 40mg, 125mg, 250mg, 500mg (injections)
– 4mg (tablets)

What is Methylprednisolone for?

Methylprednisolone belongs to a class of medications called glucocorticoids. It works by suppressing the immune system and reducing inflammation to treat various diseases. It can be used to treat, but not limited to, hematologic diseases (immune thrombocytopenia), allergies (dermatitis, drug hypersensitivity, rhinitis, asthma), gastrointestinal diseases (Crohn’s disease, ulcerative colitis), rheumatic diseases (gout, rheumatoid arthritis), neurologic diseases (multiple sclerosis) and other many autoimmune and inflammatory diseases.

How to use it?

Methylprednisolone may exist in different salt forms, which would vary the routes of administration. Methylprednisolone alone can be taken orally as tablets. Methylprednisolone sodium succinate can be injected intravenously (IV) or intramuscularly (IM), while Methylprednisolone acetate is for intramuscular (IM), intra-articular, intralesional, or soft tissue injections as suspension. Listed below are only the usual dosage ranges, in which a specific dose is determined based on clinical judgement.

Acute exacerbation of asthma:
Oral, intravenous: 40-60 mg daily in 1-2 divided doses for 3-10 days.

Acute gout attack:
Oral: 24-32 mg daily in 1-2 divided doses for 2-5 days.
Intra-articular: 10-40 mg as a single dose, based on the size of the joint.
Intramuscular: 40-60 mg as a single dose.

Intravenous: 40-125 mg as a single dose.

Acute exacerbation of multiple sclerosis:
Intravenous: 500-1000mg daily for 3-7 days.

Gastrointestinal diseases (e.g. Crohn’s disease, ulcerative colitis):
Intravenous: 40-60 mg/day.

What are the side effects of Methylprednisolone?

Common side effects of Methylprednisolone include atrophy of skin, impaired wound healing, oedema, decreased body growth in children, peptic ulcer disease, muscle weakness, cataract, depression, euphoria, congestive heart failure, or seizure.

Who should not take Methylprednisolone?

– People who are allergic to Methylprednisolone or any component of the formulation
– People who are known or suspected to be allergic to cow’s milk or its components or other dairy products (only for Methylprednisolone sodium succinate 40 mg vial)
– Patients with systemic fungal infection (except intra-articular injection)
– Premature infants (only for formulations containing benzyl alcohol preservative)

Pharmacist Tips:

– Do not suddenly stop taking this medication because it may cause severe withdrawal symptoms.
– This drug may make you more susceptible to infections. Seek medical help immediately if you have symptoms such as fever and sore throat.

Common dosing schedule:
For oral Methylprednisolone, it should be taken with food or milk in the morning.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Methylprednisolone may interact with:
– Live or attenuated vaccines
– Macrolide antibiotics, e.g. Clarithromycin, Erythromycin
– Antifungals, e.g. Ketoconazole, Itraconazole
– Anticonvulsants, e.g. Carbamazepine, Phenytoin
– Nonsteroidal anti-inflammatory drugs, e.g. Aspirin, Ibuprofen
– Antidiabetic drugs, e.g. Metformin, Empagliflozin
– Contraceptives, e.g. Ethinylestradiol

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Methylprednisolone in Hong Kong?

In Hong Kong, Methylprednisolone is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Methylprednisolone in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.