Medicines & Supplements A to Z > Mesna


Last updated on 21/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  




DRUG CLASS: Chemoprotective agents

SUB CLASS: Haemorrhagic cystitis inhibitors

USED FOR: Prevention of urothelial toxicity, Prevention of neurotoxicity associated with certain chemotherapy

AVAILABLE DOSAGE FORMS: 400 mg/4mL (injections)

What is Mesna for?

Mesna belongs to a class of medications called chemoprotective agents which converts acrolein produced in chemotherapy to something active. It is used for the prevention of urothelial toxicity and neurotoxicity associated with certain chemotherapy.

How to use it?

Mesna is injected through a needle into a vein as directed by your doctor. It follows the administration of Ifosfamide or Cyclophosphamide.

Prophylaxis against urothelial toxicity
Adult and elderly
20-40% of the IV bolus dose of Ifosfamide or Cyclophosphamide over 15-30 minutes. Repeat at 3-4 hour intervals after the first dose for at most 3 additional doses.

A shorter interval or higher dose may be required.

What are the side effects of Mesna?

Common side effects of Mesna include dizziness, drowsiness, conjunctivitis, flatulence and flushing.

Who should not take Mesna?

People allergic to Mesna or any component of the formulation.

Pharmacist Tips:

– Mesna is used with chemotherapy regimens containing Ifosfamide or Cyclophosphamide.

Common dosing schedule:
Mesna injections are prescribed in institutions by the physicians.

This schedule is for reference only, adjustments may be made according to individual needs.

Where to buy Mesna in Hong Kong?

In Hong Kong, Mesna is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Mesna in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.