Medicines & Supplements A to Z > Lacosamide

Lacosamide

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Lacosamide

CHINESE NAME: 拉考沙胺

BRAND NAME(S) IN HONG KONG: Vimpat 維帕特

DRUG CLASS: Anticonvulsants

SUB CLASS: Sodium channel blockers

USED FOR: Partial seizures, Primary generalized tonic-clonic seizures

AVAILABLE DOSAGE FORMS:
– 50mg, 100mg, 150mg, 200mg (tablets)
– 10mg/ml (syrups)
– 10mg/ml (injections)

What is Lacosamide for?

Lacosamide belongs to a class of medications called sodium channel blockers, which has the specificity to the unique part of sodium channels. It can stabilize the electrical pulse in the brain to treat partial onset seizure and primary generalized tonic-clonic seizures.

How to use it?

Lacosamide can be administered orally as tablets or syrups, and injected intravenously. Swallow the tablet whole with liquid. Do not crush, break, or chew it. Listed below are the indications and the dosages, which patients with poor renal function may need a lower dose. 

Partial onset seizure:
Patients 17 years of age and older (monotherapy):
The usual initial dose is 100 mg twice daily, and can be increased by 50 mg twice daily at weekly intervals up to a maintenance dose of 150-200 mg twice daily based on response and tolerability. 

Patients 17 years of age and older (adjunctive therapy):
The usual initial dose is 50 mg twice daily, and can be increased by 50 mg twice daily at weekly intervals up to a maintenance dose of 100-200 mg twice daily based on response and tolerability. 

Pediatric patients weighing ≥ 50 kg (monotherapy):
The usual initial dose is 50 mg twice daily, and can be increased by 50 mg twice daily at weekly intervals up to a maintenance dose of 150-200 mg twice daily based on response and tolerability. 

Pediatric patients weighing ≥ 50 kg (adjunctive therapy):
The usual initial dose is 50 mg twice daily, and can be increased by 50 mg twice daily at weekly intervals up to a maintenance dose of 100-200 mg twice daily based on response and tolerability. 

Pediatric patients weighing 30 – <50 kg (monotherapy/adjunctive therapy):
The usual initial dose is 1 mg/kg twice daily, and can be increased by 1 mg/kg twice daily at weekly intervals up to a maintenance dose of 2-4 mg/kg  twice daily based on response and tolerability. 

Pediatric patients weighing 11 – <30 kg (monotherapy/adjunctive therapy):
The usual initial dose is 1 mg/kg twice daily, and can be increased by 1 mg/kg twice daily at weekly intervals up to a maintenance dose of 3-6 mg/kg  twice daily based on response and tolerability. 

Primary generalized tonic-clonic seizures:
Patients 4 years of age and older (adjunctive therapy):
The usual initial dose is 50 mg twice daily, and can be increased by 50 mg twice daily at weekly intervals up to a maintenance dose of 100-200 mg twice daily based on response and tolerability.

What are the side effects of Lacosamide?

Common side effects of Lacosamide include diplopia, headache, dizziness,  drowsiness, or nausea.

Who should not take Lacosamide?

Patient with known cardiac conduction problems or severe cardiac disease (eg. Heart Attack, Heart Failure) should use with caution.

Pharmacist Tips:

– Do not stop taking Lacosamide suddenly as it can cause seizures.
– Do not drive, operate machinery, or do other dangerous activities until you know the effect of the medicine.

Common dosing schedule:
Lacosamide can be taken with or without food.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Lacosamide may interact with:
Phenytoin
Carbamazepine
Oxcarbazepine
– Class III antiarrhythmics, e.g. Amiodarone, Sotalol

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Lacosamide in Hong Kong?

In Hong Kong, Lacosamide is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Lacosamide in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.