Medicines & Supplements A to Z > Hyaluronidase

Hyaluronidase

Last updated on 02/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Hyaluronidase

CHINESE NAME: 透明質酸酶

BRAND NAME(S) IN HONG KONG: Hylase, Hyalase

DRUG CLASS: Dermatological drugs

SUB CLASS: Enzymes

USED FOR: Facilitate drug injections, surgical anaesthesia, drug extravasation, subcutaneous urography

AVAILABLE DOSAGE FORMS:
– 1500IU (injections)

What is Hyaluronidase for?

Hyaluronidase is an enzyme that degrades hyaluronic acid. Hyaluronic acid is found in connective tissues under the skin to provide structure and elasticity. Hyaluronidase breaks down hyaluronic acid to make injections under the skin easier and enhances the absorption of drugs into tissue. In extravasation of a drug (leakage from blood vessels into tissues), hyaluronidase is used to minimize subsequent injuries. Hyaluronidase is commonly used in eye surgeries, local anaesthesia and subcutaneous urography.

How to use it?

Hyaluronidase is injected through a needle under the skin as directed by your doctor. Your doctor will advise you on the dosage depending on your condition.

Facilitate subcutaneous or intramuscular injections
Adult
1500 units directly added to the injection.

Enhance diffusion of local anaesthetics in eye surgeries
Adult
15 units/ml mixed with the local anaesthetic solution.

Enhance diffusion of local anaesthetics in other surgeries
Adult
1500 units mixed with the local anaesthetic solution.

Aid in the dispersal of extravasated fluids or blood
Adult
Inject 1500 units in 1 ml of water for injection or normal saline into the affected area.

What are the side effects of Hyaluronidase?

Common side effects of Hyaluronidase include oedema and swelling around the eyes.

Who should not take Hyaluronidase?

– People allergic to Hyaluronidase or any component of the formulation
– People with infection or malignancy at injection site
– People that need to reduce swelling of bites and stings

Pharmacist Tips:

Hyaluronidase may be used to help inject other medicines or during medical procedures like subcutaneous urography.

Common dosing schedule:
Please refer to your medical professionals.

Some common medications Hyaluronidase may interact with:
– Sympathomimetics, e.g. Phenylephrine, Methyldopa
– Systemic corticosteroids, e.g. Hydrocortisone, Prednisone
– Estrogen derivatives, e.g. Estradiol
– Salicylates, e.g. Aspirin
Dopamine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Hyaluronidase in Hong Kong?

In Hong Kong, Hyaluronidase is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Hyaluronidase in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.