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Fingolimod

Last updated on 21/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Fingolimod

CHINESE NAME: 芬戈莫德

BRAND NAME(S) IN HONG KONG: Gilenya

DRUG CLASS: Immunosuppressants

SUB CLASS: Sphingosine 1-phosphate receptor modulator

USED FOR: Multiple sclerosis

AVAILABLE DOSAGE FORMS:
– 0.25 mg, 0.5 mg (capsules)

What is Fingolimod for?

Fingolimod is an immunosuppressant that can act on sphingosine-1-phosphate (S1P) receptors to reduce the number of lymphocytes in the central nervous system. Fingolimod is used for multiple sclerosis.

How to use it?

Fingolimod is available in Hong Kong as oral capsules. It can be taken with or without food. Listed below are the indications and the dosages.

Relapsing multiple sclerosis
Child above 10 years of age and weighed heavier than 40 kg, adult and elderly
0.5 mg once daily.

Child above 10 years of age and weighed lighter than 40 kg
0.25 mg once daily.

What are the side effects of Fingolimod?

Common side effects of Fingolimod include increased gamma-glutamyl transfer, diarrhoea, nausea, bradycardia, increased liver enzymes, influenza, headache, cough and sinusitis.

Who should not take Fingolimod?

– People who are allergic to Fingolimod or any component of the formulation.
– Patients with cardiovascular diseases.
– Patients with an increased risk of infection and a severe infection.
– Patients with severe hepatic impairment.
– Pregnant or breastfeeding women and those who intend to become pregnant.

Pharmacist Tips:

– Due to its characteristic bradycardia and increased risk of infection, for the first dose of Fingolimod, the first dose should be administered followed by a 6-hour monitoring. Moreover, the first dose and the dose after a 14-day or more interruption should be done in a setting with adequate equipment to manage the symptomatic bradycardia.
– Consider undergoing physical therapy.
– Get more sleep since multiple sclerosis causes much fatigue. Rest more to make yourself feel more refreshed.
– Cool down yourself by avoiding sources of heat or sunlight.

Common dosing schedule:
Fingolimod is taken once daily. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Fingolimod may interact with:
– Agents that cause bradycardia, e.g. Metoprolol, Diltiazem, Digoxin
– Immunosuppressants, e.g. Tacrolimus, Everolimus, Etanercept
– QT-prolonging agents, e.g. Sertraline, Haloperidol, Levofloxacin
– Vaccines, e.g. BCG, Smallpox and Monkeypox, COVID-19

Fingolimod may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Fingolimod in Hong Kong?

In Hong Kong, Fingolimod is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Fingolimod in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.