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Evolocumab

Last updated on 30/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Evolocumab

CHINESE NAME: 依伏庫人單抗

BRAND NAME(S) IN HONG KONG: Repatha 立控醇

DRUG CLASS: Lipid-regulating drugs

SUB CLASS: Monoclonal antibodies, PCSK9 inhibitors

USED FOR: Hyperlipidemia, Prevention of cardiovascular events

AVAILABLE DOSAGE FORMS:
– 140mg/ml (injections)

What is Evolocumab for?

Evolocumab, which is a monoclonal antibody, belongs to a class of medications called PCSK9 inhibitors. It can inhibit a substance in the body to boost the ability of the liver to uptake lipids, thus lowering cholesterol level in blood. Although Evolocumab can greatly reduce low-density lipoprotein (LDL, “bad cholesterol”) levels, It is not the first-line agent for hyperlipidemia in Hong Kong due to its price and route of administration. The detailed indications include:
– homozygous familial hypercholesterolemia (HoFH)
– primary hyperlipidemia, including heterozygous familial hyperlipidemia (HeFH)
– prevention of cardiovascular events (e.g. stroke, myocardial infarction) in patients with established cardiovascular disease

How to use it?

Evolocumab is administered subcutaneously. 

For homozygous familial hypercholesterolemia (HoFH):
420 mg once monthly, and may increase to 420 mg once every 2 weeks if clinically meaningful response is not achieved in 12 weeks. It is used as an adjunct to other LDL–lowering therapies.

For hyperlipidemia and prevention of cardiovascular events in patients with established cardiovascular disease:
140 mg every 2 weeks OR 420 mg once monthly. It is used as an adjunct to diet, alone or in combination with other LDL-lowering therapies.

What are the side effects of Evolocumab?

Common side effects of Evolocumab include nasopharyngitis, upper respiratory tract infection, back pain, injection site reactions.

Who should not take Evolocumab?

People allergic to Evolocumab, latex, or any components of the formulation.

Pharmacist Tips:

– Do not shake the medication.
– Remove one prefilled syringe from the refrigerator and wait 30 minutes to allow it to reach room temperature. Do not speed up the warming process in any way, such as using the microwave or placing the syringe in warm water. Also, do not remove the needle cover while allowing the prefilled syringe to reach room temperature.
– If you need to use the 420 mg dosage, give 3 separate subcutaneous injections consecutively within a 30-minute period.
– Each prefilled syringe is for one use only.
– Change (rotate) your injection site with each injection. Do not use the same site for each injection.
– Lifestyle modification is the first line treatment for hyperlipidemia, which includes a healthy diet, regular exercise and weight management.

Common dosing schedule:
Evolocumab can be injected into the thigh, upper arm, or abdomen at any time of a day, except for a two-inch area around your belly button.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Evolocumab may interact with:
No known significant interactions.

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Evolocumab in Hong Kong?

In Hong Kong, Evolocumab is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Evolocumab in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.