Medicines & Supplements A to Z > Eplerenone


Last updated on 12/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Eplerenone



DRUG CLASS: Antihypertensives, Diuretics

SUB CLASS: Potassium sparing diuretics, Aldosterone receptor antagonist

USED FOR: High blood pressure, congestive heart failure, myocardial infarction

–  25 mg, 50 mg (tablets)

What is Eplerenone for?

Eplerenone belongs to a class of medications called aldosterone receptor antagonists (or potassium sparing diuretics). It helps your body to get rid of salt and water more easily by increasing the volume of your urine output. Eplerenone can be used to treat high blood pressure and congestive heart failure.

How to use it?

Eplerenone is taken by mouth as tablets. It may be taken with or without food. Take diuretics before midday (morning or early afternoon) to avoid excessive urination overnight.

High blood pressure
Initially 50 mg once daily, may increase to a maximum of 50 mg twice daily if necessary.

Congestive heart failure after myocardial infarction
Initially 25 mg once daily, may increase to 50 mg once daily within 4 weeks if necessary.

What are the side effects of Eplerenone?

Common side effects of Eplerenone include diarrhea, nausea, pain, dizziness, insomnia and high blood potassium levels.

Who should not take Eplerenone?

– People allergic to Eplerenone or any ingredient of the formulation
– Patients with hyperkalemia (high potassium level in blood)

Pharmacist Tips:

– This medication can make you dizzy. Avoid driving or operating machinery until you know how you respond to Eplerenone.
– Avoid any supplements that contain potassium and potassium-rich food while taking this medication.

Common dosing schedule:
Eplerenone may be taken with or without food. Do not take Eplerenone in the late afternoon to avoid going to the toilet while sleeping.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Eplerenone may interact with:
Potassium supplements
– Angiotensin converting enzyme inhibitors, e.g. Captopril, Lisinopril
– Angiotensin II receptor antagonists, e.g. Losartan, Valsartan
– Non-steroidal anti-inflammatory drugs, e.g. Ibuprofen, Ketorolac, Mefenamic Acid

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Eplerenone in Hong Kong?

In Hong Kong, Eplerenone is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Eplerenone in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.