Medicines & Supplements A to Z > Entresto


Last updated on 19/10/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Sacubitril + Valsartan


DRUG CLASS: Cardiovascular agent

SUB CLASS: Neprilysin inhibitor, Angiotensin II receptor blockers

USED FOR: Symptomatic Chronic Heart Failure

– 50mg, 100mg, 200mg (tablets)

What is Entresto for?

Entresto is a brand product that contains Sacubitril and Valsartan, which is a neprilysin inhibitor and angiotensin receptor blocker respectively. Sacubitril helps relax blood vessels and decrease sodium and fluid in the body, while Valsartan reduces blood vessel tightening and the build-up of sodium and fluid. They work in synergy to help improve your heart’s ability to pump blood to the body, hence indicated for the treatment of heart failure.

How to use it?

Entresto is available as tablets. The recommended starting dose is 100 mg twice daily. Within 2-4 weeks to reach a target maintenance dose of 200 mg twice daily. 

Paediatric patients or patients with renal/hepatic impairment may require a lower dose.

What are the side effects of Entresto?

Common side effects of Entresto include dizziness, light-headedness, and coughing. In rare cases, an allergic reaction might happen, which include symptoms like difficulty breathing, hives, swelling of face, lips.

Who should not take Entresto?

– People who are allergic to sacubitril, valsartan, or any component of the formulation.
– Patients with history of angioedema related to previous ACE inhibitor or ARB therapy
Pregnant or breastfeeding women

Pharmacist Tips:

– Avoid standing up too fast as it may make you feel more dizzy.
– Do not take any potassium supplements while taking this medicine.
– Avoid alcohol use while taking this medicine as it can enhance drowsiness. 

Common dosing schedule:
Entresto should be taken twice daily, with or without food. You can take it in the morning and evening.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Entresto may interact with:
– Aliskiren
– Potassium-sparing diuretics, e.g. Spironolactone, Amiloride
– ACE inhibitors, e.g. Captopril, Enalapril
– Nonsteroidal anti-inflammatory drugs, e.g. Ibuprofen, Aspirin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Entresto in Hong Kong?

In Hong Kong, Entresto is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Entresto in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.