Medicines & Supplements A to Z > Enoxaparin

Enoxaparin

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Enoxaparin

CHINESE NAME: 依諾肝素

BRAND NAME(S) IN HONG KONG: Clexane

DRUG CLASS: Anticoagulants

SUB CLASS: Low Molecular Weight Heparin

USED FOR: Ischemic heart disease, Treatment of venous thromboembolism (VTE), Prophylaxis of venous thromboembolism (VTE), Unstable angina, Acute myocardial infarction

AVAILABLE DOSAGE FORMS:
– 20mg/0.2ml, 40mg/0.4ml (injections)

What is Enoxaparin for?

Enoxaparin belongs to a class of medications called low molecular weight heparin. It can inhibit several substances involved in the blood clotting process to reduce blood clot formation in your body. It is indicated for unstable angina, myocardial infarction, prevention and treatment of venous thromboembolism (e.g. deep vein thrombosis (DVT)).

How to use it?

Enoxaparin is usually administered by subcutaneous injection for most conditions, but sometimes can be administered by intravenous injection. Listed below are the indications and usual adult dosages, which renal imparied patients, children and elderly may need a lower dose. 

For unstable angina, non-ST segment elevation myocardial infarction (non-STEMI):
1 mg/kg subcutaneously every 12 hours for 2-8 days, with oral Aspirin 100-325 mg

For acute ST segment elevation myocardial infarction (STEMI):
30 mg single intravenous bolus plus a 1 mg/kg subcutaneous dose followed by 1 mg/kg subcutaneously every 12 hours for at least 8 days, with oral Aspirin 75-325 mg.

For prophylaxis of DVT in knee or hip replacement surgeries:
30 mg subcutaneously every 12 hours up to 14 days OR 40 mg subcutaneously once daily up to 14 days. The usual duration of administration is 7-10 days.

For prophylaxis of DVT in abdominal surgery:
40 mg subcutaneously once daily up to 12 days. The usual duration of administration is 7-10 days.

For prophylaxis of DVT in medical patients during acute illness:
40 mg subcutaneously once daily up to 14 days. The usual duration of administration is 6-11 days.

For outpatient treatment of acute DVT without pulmonary embolism:
1 mg/kg subcutaneously every 12 hours up to 17 days. Initiate warfarin sodium when appropriate (usually within 72 hours of Enoxaparin), then continue Enoxaparin for at least 5 days and until a therapeutic anticoagulant effect is achieved (INR 2-3).

For inpatient treatment of acute DVT with or without pulmonary embolism:
1 mg/kg subcutaneously every 12 hours up to 17 days. Initiate warfarin sodium when appropriate (usually within 72 hours of Enoxaparin), then continue Enoxaparin for at least 5 days and until a therapeutic anticoagulant effect is achieved (INR 2-3).

What are the side effects of Enoxaparin?

Common side effects of Enoxaparin include anemia, oedema, diarrhea, nausea, or  fever.

Who should not take Enoxaparin?

– People who are allergic to Enoxaprarin sodium, Heparin, pork products, benzyl alcohol, or any component of the formulation
– Patients with active major bleeding
– History of immune-mediated heparin-induced thrombocytopenia (HIT) within the past 100 days or in presence of circulating antibodies

Pharmacist Tips:

– You may be taught how to inject your medicine at home.
– The injection site should be on the left or right side of the abdominal wall, which is approximately 3 inches from the belly button.
– Do not inject into muscle and avoid injecting into bruised or scarred skin areas.
– It is important to change your injection sites every time you inject.
– Wash your hands with soap and water before and after using.
– Sit or lie down with your abdomen in view.
– To minimize bruising, do not rub the injection site after completion of the injection.
– Enoxaparin may increase the risk of bleeding and it may take them longer than usual to stop bleeding. However, if unusual/excessive bleeding occurs, report to your doctor immediately.

Common dosing schedule:
N/A

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Enoxaparin may interact with:
– Aspirin
– Warfarin
– Clopidogrel
– Dipyridamole
– Nonsteroidal Anti-inflammatory Drugs, e.g. Ibuprofen, Naproxen, Piroxicam

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Enoxaparin in Hong Kong?

In Hong Kong, Enoxaparin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Enoxaparin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.