> Western Medicines > Dothiepin


Used for: Depression
Chinese name:

What is Dothiepin for?

Dothiepin belongs to a class of medication called tricyclic antidepressants. It is used for acute and maintenance treatment of depression.

How to use it?

Dothiepin can be taken orally as tablets or capsules. The usual initial dose is 25 mg three times a day or 75 mg as a single daily dose at bedtime. You may gradually increase the dose by 25-50 mg at intervals of 1-2 weeks if response is inadequate, of which up to 150 mg of the daily dose can be given as a single dose at bedtime. The maximum daily dose is 225 mg/day.

Swallow the tablets or capsules whole with a glass of water. Do not crush or chew it.

What are the side effects of Dothiepin?

Common side effects of Dothiepin include dry mouth, constipation, dizziness, or headache.

Who should not take Dothiepin?

  • People who are allergic to Dothiepin or any component of the formulation
  • Patients during the acute recovery period after a myocardial infarction
  • Patients taking monoamine oxidase inhibitors, such as Selegiline, Rasagiline
  • Patients with glaucoma, urinary problems, epilepsy, liver problems

Pharmacist Tips:

It might take a few weeks for Dothiepin to reach its full effect. Do not stop taking Dothiepin suddenly during that time.


Common dosing schedule:
Administer in divided doses or as a single dose at night. The larger dose should be administered at night as it may produce drowsiness.


This schedule is for reference only, adjustments may be made according to individual needs.


Some common medications Dothiepin may interact with:

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Dothiepin in Hong Kong?

In Hong Kong, Dothiepin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.


For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Dothiepin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.

Brands in Hong Kong
Available dosage
  • 75mg (Tablets)
  • 25mg (Capsules)
Drug class
Sub class
Tricyclic Antidepressants (TCAs)
Alternative Names
Other drugs in same class
Used for: Depression
Chinese name:
Used for: Major depression, Nocturnal enuresis in children
Chinese name:
Used for: Depression
Chinese name:
Used for: Depression
Chinese name: