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Dimethyl fumarate

Last updated on 04/08/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Dimethyl fumarate

ALTERNATIVE NAME: DMF

CHINESE NAME: 富馬酸二甲酯

BRAND NAME(S) IN HONG KONG: Tecfidera 

DRUG CLASS: Immunomodulatory drugs

SUB CLASS: Fumaric acid derivatives, Nrf2 activators

USED FOR: Multiple sclerosis

AVAILABLE DOSAGE FORMS:
– 120mg, 240mg (gastro-resistant capsules)

What is Dimethyl fumarate for?

Dimethyl fumarate is a Nrf2 activator derived from fumaric acid. It is used to treat multiple sclerosis and is claimed to have neuroprotective and anti-inflammatory effects.

How to use it?

Dimethyl fumarate is taken orally as tablets. The usual initial dose is 120 mg twice daily for 7 days and increases to 240 mg twice daily thereafter. Swallow the capsule whole. Do not crush, chew or open the capsule.

What are the side effects of Dimethyl fumarate?

Common side effects of Dimethyl fumarate include flushing, abdominal pain, diarrhea, infection, and nausea.

Who should not take Dimethyl fumarate?

People who are allergic to Dimethyl fumarate or any component of the formulation.

Pharmacist Tips:

– This drug may cause serious liver problems. Report any symptoms immediately such as fatigue, abdominal pain, loss of appetite, itching, bruising, and yellow skin or eyes.
– This drug may make you more susceptible to infections (such as shingles). Seek medical help immediately if you have symptoms such as fever, sore throat, rash and pain.

Common dosing schedule:
Dimethyl fumarate can be taken with or without food. 

However, administering with high-fat, high-protein food (e.g. yogurt or peanut butter) may decrease the incidence of flushing and GI effects. On the other hand, administration of non-enteric coated Aspirin (up to a dose of 325 mg) 30 minutes prior to Dimethyl fumarate may also reduce the incidence of flushing.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Dimethyl fumarate may interact with:
No significant drug interactions.

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Dimethyl fumarate in Hong Kong?

In Hong Kong, Dimethyl fumarate is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Dimethyl fumarate in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.