Dexmedetomidine
What is Dexmedetomidine for?
Dexmedetomidine is a selective alpha-2 agonist which reduces the suppression of respiration compared to opioids and other sedatives. It is used for sedation of:
- initially intubated and mechanically ventilated patients during treatment in an intensive care setting (ICU) and
- non-intubated patients prior to and/or during procedures.
How to use it?
Dexmedetomidine is injected intravenously.
For sedation of mechanically ventilated patients in the ICU:
0.2-0.7 mcg/kg/hour, adjusted according to response.
For procedural sedation:
Loading dose is 1 mcg/kg over 10 minutes, followed by a maintenance dose of 0.2-1 mcg/kg/hour.
What are the side effects of Dexmedetomidine?
Common side effects of Dexmedetomidine include hypotension, bradycardia, dry mouth, respiratory failure, constipation, and agitation.
Who should not take Dexmedetomidine?
- People who are allergic to Dexmedetomidine or any components of the formulation.
Pharmacist Tips:
- Avoid drinking and driving or operating machinery until the effects of this drug wear off and you feel fully awake.
Common dosing schedule:
N/A
Some common medications Dexmedetomidine may interact with:
- Beta-blockers, e.g. Propranolol, Metoprolol
- Sedatives, e.g. Phenobarbital, Zolpidem
- First-generation antihistamines, e.g. Chlorpheniramine, Diphenhydramine
- Benzodiazepines, e.g. Diazepam, Lorazepam
Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.
Where to buy Dexmedetomidine in Hong Kong?
In Hong Kong, Dexmedetomidine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Dexmedetomidine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.
- 100mcg/ml / 200mcg/50ml / 200mcg/2ml (Injections)