Medicines & Supplements A to Z > Daptomycin


Last updated on 05/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Daptomycin



DRUG CLASS: Antibiotics

SUB CLASS: Cyclic Lipopeptide

USED FOR: Complicated skin and skin structure infections (cSSSI), Staphylococcus aureus bloodstream infections

– 500 mg (injections)

What is Daptomycin for?

Daptomycin belongs to a class of medications called cyclic lipopeptide antibiotics. It kills bacteria by interrupting the integrity of bacterial cell walls. It is used to treat blood infections and serious skin infections caused by bacteria in adults and children over 1 year old. Daptomycin does not work for virus or fungus infections.

How to use it?

Daptomycin is injected through a needle into a vein as directed by your doctor. Your doctor will advise you on the dosage and frequency depending on your infection.

Complicated skin and skin structure infections
4 mg/kg body weight once daily for 7-14 days.
Child 12-17 years
5 mg/kg body weight once daily for up to 14 days.
Child 7-11 years
7 mg/kg body weight once daily for up to 14 days.
Child 2-6 years
9 mg/kg body weight once daily for up to 14 days.
Child 12-23 months
10 mg/kg body weight once daily for up to 14 days.

Staphylococcus aureus bloodstream infections
6 mg/kg body weight once daily for 2-6 weeks.

What are the side effects of Daptomycin?

Common side effects of Daptomycin include anaemia, anxiety, constipation, diarrhoea, dizziness, fever, headache, nausea and vomiting, gastrointestinal discomfort, insomnia, and allergic skin reactions.

Who should not take Daptomycin?

People allergic to Daptomycin or any component of the formulation.

Pharmacist Tips:

– Report severe diarrhoea and ask your doctor or pharmacist before taking antidiarrheal medicines.
– Drink plenty of water to replace any lost fluids due to diarrhoea.
– If you experience symptoms of muscle pain or muscle weakness, especially in the limbs and extremities, report to your doctor or pharmacist immediately.

Common dosing schedule:
Daptomycin is administered once daily.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Daptomycin may interact with:
– HMG-CoA reductase inhibitors, e.g. Atorvastatin, Lovastatin, Simvastatin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Daptomycin in Hong Kong?

In Hong Kong, Daptomycin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.  

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at

Need more information?

For detailed information about the use of Daptomycin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.